Important cytokines

Question 1

Fxn of IL-8?

Answer 1

chemotactic factor for neutrophils

Question 2

Fxn of IL-4

Answer 2

Induces the diffrentiation of T-cells to Th (helper) 2 cells –> promots the growth of B-cells –> Enhances class switching to IgE (and IgG)

Acronim: 2 BEG 4 help

* part of Type I hyper

Question 3

Fxn of IL-5

Answer 3

recruits and activates eosinophils

* Part of type I hyper

Question 4

Fxn of IL-13

Answer 4

same as IL-4
* promotes class switching to IgE by B cell maturation

Question 5

Fxn of TNF-α

Answer 5

mediates fever and sepsis

Question 6

Fxn of IL-6

Answer 6

Lymphocyte activation -> increased Ab production
(Causes fever, induces CRP production)

Question 7

Fxn of IL-12

Answer 7

activation of T cells –> IFN-γ (maintain granulomas)