Week 1 Flashcards
Give examples of connective tissue structures
Ligaments
tendons
fascia
Bone
Cartilage
Skin
Muscles
Nerves
Arteries
Joint capsules
Adipose tissue
Give examples of connective tissue types
1) bone:
Compact, spongy
2) cartilage:
Hyaline, elastic, fibrocartilage
3) connective tissue proper:
A) Loose:
Areolar, adipose, reticular
B) Dense:
Regular, irregular, elastic
What is the function, location and cellular description of adipose CT?
Function:
Protects and insulates, stores fat
Location & cellular description:
Beneath skin, around kidneys, behind eyes, on surface of heart, cells in fluid-gel like matrix
What is the function, location and cellular description of areolar CT?
Function:
binds organs
Location & cellular description:
Beneath skin, surrounding organs, cells in fluid-gel like matrix
What is the function, location and cellular description of blood?
function:
Transports gases, defends against disease, acts in clotting
Location & cellular description:
Throughout the body in close system of blood vessels and heart chambers, cells and platelets in fluid matrix
What is the function, location and cellular description of bone?
function:
Supports and protects, provides framework
Location & cellular description:
Bones of skeleton and in middle ear, cells in solid matrix
What is the function, location and cellular description of cartilage?
Function:
1) Cartilage (supports and protects)
2) elastic cartilage (provides flexible framework)
3) fibrocartilage (absorbs shock)
4) hyaline cartilage (provides framework)
Location & cellular description:
1) cells in solid-gel like matrix
2) external ears, part of larynx
3) between bony parts of spinal column, parts of pelvic girdle, and knee
4) ends of bones, nose, and rings in respiratory passage walls
What is the function, location and cellular description of dense irregular CT?
function:
Sustains body parts
Location & cellular description:
Dermis, cells in fluid-gel like matrix
What is the function, location and cellular description of dense regular CT?
function:
Binds body parts
Location & description:
Tendons, ligaments, cells in fluid-gel like matrix
What is the function, location and cellular description of elastic CT?
function:
Provides elasticity
Location & description:
Connects parts of spinal column, also in walls of arteries and airways, cells in fluid-gel like matrix
What is the function, location and cellular description of reticular CT?
function:
Provides support
Location & description:
Walls of liver and spleen, cells in fluid-gel like matrix
What is the location and function of fibroblast?
Location:
In tendon, ligament, skin, bone
Function:
Creates mostly Type I Collagen
What is the location and function of chondroblast?
location:
Fibroblast found in cartilage
Function:
Produces mostly Type II Collagen
What is the location and function of osteoblast?
location:
Fibroblast found in bone
Function:
Produces Type I Collagen and Hydroxyapatite (responsible for bone regeneration)
What is the location and function of osteoclast?
location:
Found in bone
Function:
Responsible for bone resorption
Define extracellular matrix (ECM)
It is the non-cellular component
present within all tissues and organs and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue morphogenesis, differentiation, and
homeostasis
What is the arrow pointing to?
Ground substance (it is high in water content)
What are the components of the ECM? What is it primarily for?
▪ Primary factor required in forming a new network of tissue.
Contains water, and a mixture of various proteins
▪ Critical in rehabilitation and
regeneration of various types of
connective tissue structures.
▪ ECM can include the following:
1. Collagen 2. Proteoglycans 3. Elastin 4. Aggrecan
Define collagen
Building block to connective tissue regeneration after injury.
- Over 28 types of collagen in the human body.
- Only 4 predominate in the make-up of connective tissues:
1. Type 1-Most common in the body. Greatest tensile strength of all collagen. (95% of compact bone is made up from this)
2. Type 2-Found in discs and cartilage. Places with high compressive forces
3. Type 3-Activated immediately after injury. Converts to Type 1. - Areas that withstand high turnover (tensile forces)
4. Type 4-Found primarily in the basil membrane of the skin.
Label the structures
A) loose CT
B) Fibrous CT
C) Adipose tissue
D) Cartilage
E) Bone
F) Blood
What is the structure
Crimp: wave like formation of collagen
Define proteoglycans
functions:
1. Water binding—Carry negative charge and draws water for hydration
- Gives infrastructure necessary to withstand compression
▪ Contains approximately 100 glycosaminoglycans (GAGs)
Define aggrecan
it is a type of proteoglycan found in cartilage
▪ Contains chondroitin sulfate and keratin sulfate
Define elastin
important features:
* Second most abundant component
found in ECM.
* Uncoils and recoils when forces are presented or removed from a structure.
* Tissues that have more “give” contain
more elastin than collagen
* Cross-links expand during stretch
creating more pliability with force
application.
* Found in high content in the dermis of the skin, and arteries
What test can be done to check elastin’s functionality?
turgor test:
Pinch skin and release to check if it returns to normal (abnormal, skin remains elevated after being released)
Explain the stretched/relaxed states of elastin
Relaxed:
Elastin polypeptide chains are cross-linked together to form rubberlike, elastic fibers.
Stretched:
Each elastin molecule uncoils into a more extended conformation when the fiber is stretched and recoils spontaneously as soon as the stretching force is relaxed.
what are ligaments made of? What’s their properties? How does it respond to rehab?
▪ 90% Type 1 collagen; ~5% dry weight elastin composition
▪ Highly resistive to tensile forces
▪ Collagen oriented in various crosslinks that create stability in withstanding forces from multiple directions
▪ Response to Rehabilitation:
Successful ligamentous treatment interventions incorporate multidirectional loading and challenge.
what are tendons made of? What’s their properties? How does it respond to rehab?
▪ 65-85%- Type I collagen-high resistive capacity to tensile forces; ~1-2% dry weight elastin makeup.
▪ Can rupture if exposed to: Corticosteroids, nutritional deficiencies, hormonal imbalances, dialysis, and chronic loading without adequate recovery periods
▪ Response to Rehabilitation:
Tendons are treated successfully with progressive tensile loading programs
Label the structures
1) muscle fiber
2) blood vessels
3) perimysium
4) epimysium
5) fascicle (wrapped by perimysium)
6) endomysium
7) sharpey’s fibers
8) epitendon
9) endotendon
10) endotendon
11) collagen micro fibrils
12) tropocollagen
What is the structure?
Tendon, dense regular CT