Week 1 Flashcards
SNS response?
fight or flight
PNS response?
rest and digest
all adrenergic receptor subtypes are what kind of receptors?
G protein coupled receptors
Receptor: a1
effector enzyme/function?
2nd messengers?
activate phospholipase C to increase extracellular calcium
IP3, DAG, and Ca2+
Receptor: a2
effector enzyme/function?
2nd messengers?
inhibit adenylyl cyclase to open potassium channels
decrease cyclic AMP (CAMP)
Receptor: B
effector enzyme/function?
2nd messengers?
activate adenylyl cyclase to catalyze the conversion of ATP
increase cyclic AMP (CAMP)
Increasing CAMP:
effect on smooth muscle?
effect on cardiac muscle?
what increases CAMP?
relaxes SM
contracts CM
B agonists
Decreasing CAMP:
effect on smooth muscle?
effect on cardiac muscle?
what decreases CAMP in smooth muscle? cardiac muscle?
contracts SM
relaxes CM
SM: B agonists
CM: muscarinic agonists
which receptor is an important vasoconstrictor in the blood vessels of SM?
how does this effect BP?
a1 adrenergic receptor
increases BP
which receptor usually increases CAMP production in SM? what effect does this have on SM?
B2-adrenergic receptor
relaxes SM
what is the effect of an agonist on a2 receptors on the neuron?
hyperpolarize to inhibit NE and create a negative feedback loop
what drug class is Rserpine? what does it block?
anti-psychotic, blocks dopamine uptake
T/F NET is highly selective for NE and will not transport epi or dopamine
True
what is cocaines involvement with NE?
what is the outcome effect?
what class is cocaine/tricyclic depressants considered?
it blocks the reuptake of NE
potent vasoconstriction, stimulation, inc BP
indirect agonists-reuptake blockers
what is tyramine/amphetamine's involvement with NE? what class are they considered?
competes with NET preventing reuptake of NE
indirect agonists-reuptake competitors
