Acetylcholinesterase Inhibition Flashcards
what are AChE inhibitors a treatment for?
myasthenia gravis
reversal of paralysis caused by neuromuscular blockers
orthostatic hypotension
glaucoma
poisoning by atropine/muscarinic antagonists
Alzheimer’s disease
how long are AChE inhibitors effective for treating Alzheimer’s disease?
6-12 months
what are the side effects of AChE inhibitors?
muscarinic side effects: increased secretion, bronchoconstriction
if passes BBB, increase BP
strengthens neuromuscular effects
CNS effects such as confusion
older patients with what disorder would not benefit from the muscarinic side effects of AChE inhibitors?
overactive bladder
how can AChE inhibitors increase BP?
they stimulate post-ganglionic sympathetic nerves by increasing ACh which will increase NorEPI release to constrict blood vessels increasing BP
Physostigmine:
drug class?
use?
AChE inhibitor
orthostatic hypotension
Neostigmine
drug class?
use?
AChE inhibitor
myasthenia gravis
Edrophonium
drug class?
use?
AChE inhibitor
used to diagnose myasthenia gravis
Pyridostigmine
drug class?
use?
AChE inhibitor
prophylactic for nerve gas attack and myasthenia gravis
Rivastigmine
drug class?
use?
AChE inhibitor
Alzheimer’s disease
Donepezil
drug class?
use?
AChE inhibitor
Alzheimer’s disease
Galantamine
drug class?
use?
AChE inhibitor
Alzheimer’s disease
Huperzine A
drug class?
use?
AChE inhibitor
Alzheimer’s disease
Echothiophate
drug class?
use?
Organophosphate (AChE inhibitor)
topically for glaucoma
Sarin, Tabun, Soman, VX
drug class?
use?
Organophosphate (AChE inhibitor)
nerve gas to cause asphyxiation
