Muscarinic agonists

Question 1

which two eye muscles are affected by the PNS?

Answer 1

ciliary muscle and concentric muscle

Question 2

Muscarinic agonists will have what effect on GI?

Answer 2

stimulate rest and digest

Question 3

Muscarinic agonists will have what effect on urinary tract?

Answer 3

relaxation

Question 4

Muscarinic agonists will have what effect on heart?

Answer 4

slow HR

Question 5

Muscarinic agonists will have what effect on lungs?

Answer 5

constriction

Question 6

Muscarinic agonists will have what effect on glands?

Answer 6

increased secretion

Question 7

Muscarinic agonists will have what effect on the eye?

Answer 7

contract concentric muscle of iris

Question 8

T/F blood vessels are not effected by muscarinics

Answer 8

True

Question 9

T/F ACh doesn’t last long enough to reach blood vessels

Answer 9

True

Question 10

The role of the PNS is to keep things moist. What does this acronym stand for : SLUDS BB

Answer 10

Salivation
Lacrimation
Urination
Defecation
Sweat
Bronchoconstriction
Bradychardia

Question 11

Muscarinic agonists contract the concentric muscle of the iris in acute glaucoma causing?

Answer 11

myosis (pupil constriction)

Question 12

Muscarinic antagonists cause what effect on the concentric muscle of the iris?

Answer 12

mydriasis (pupil dilation)

Question 13

pupil dilation is also known as?

Answer 13

mydriasis

Question 14

contraction of ciliary muscle causes constriction or dilation of pupil?

Answer 14

constriction (myosis, see up close)

Question 15

What transporter brings in choline to cholinergic nerve terminal?

Answer 15

choline uptake transport

Question 16

what enzyme combines choline to make ACh?

Answer 16

choline acetyl transferase

Question 17

once ACh is produced inside cholinergic nerve terminal, it is packaged into vesicles by entering through?

Answer 17

vesicular ach transport

Question 18

Ach is only release from the cholinergic nerve terminal upon what conditions?

Answer 18

an action potential is induced via a calcium-dependent reaction

Question 19

what toxin blocks the proteins which transport ACh out of the nerve terminal?

Answer 19

Botulinum toxin

Question 20

Botulinum toxin primarily targets skeletal or smooth muscle?

Answer 20

skeletal

Question 21

Botulinum toxin is more commonly known as?

Answer 21

Botox

Question 22

once ACh is released, it is rapidly metabolized by?

Answer 22

Acetylcholinesterase

Question 23

what receptor opens Ka+ channels and inhibits Ach release? Is it a M1, M2, M3, or M4?

Answer 23

M2 acetylcholine autoreceptor

Question 24

M1 receptors cause contraction of?

Answer 24

smooth muscle

Question 25

M1 receptors are similar to what agonistic effect we’ve discussed previously?

Answer 25

contraction by alpha1 agonists

Question 26

what effect do M1 receptors have on glands?

Answer 26

promote secretion

Question 27

what do M1 receptors release?

Answer 27

Calcium

Question 28

T/F bodily secretions are calcium-dependent processes

Answer 28

True

Question 29

M2 receptors open what channels?

this causes a decrease in?

Answer 29

potassium

cAMP

Question 30

M2 receptor activation has what effect on the heart?

Answer 30

decreases HR

Question 31

T/F there are M2 receptors directly on the heart

Answer 31

true

Question 32

how does the PNS relax the sphincter muscle?

Answer 32

it releases ACh onto sympathetic nerve which is taken in by M2 receptors to inhibit NE release