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Patho > WBC, LN, Spleen, Thymus > Flashcards

WBC, LN, Spleen, Thymus Flashcards

1
Q

Most common cause of agranulocytosis

A

Drug toxicity

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2
Q

Clinically significant neutropenia <500/mm3

A

Agranulocytosis

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3
Q

What type of infections is the patient highly susceptible to when he has agranulocytosis?

A

Candida and Aspergillus

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4
Q

Most common cancer of children

A

ALL

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5
Q

Most common leukemia of adults in Western world

A

CLL/ SLL

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6
Q

Most common indolent lymphoma of adults

A

Follicular lymphoma

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7
Q

Most common lymphoma of adults

Most common form of Non Hodgkins lymphoma

A

Diffuse large B cell lymphoma

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8
Q

Fastest growing human tumor

A

Burkitt lymphoma

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9
Q

Early childhood
Bone marrow failure
T 12:22, t 9:22 mutation
Large hypercellular marrow with lymphoblasts

A

B-cell Acute Lymphoblastic leukemia

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10
Q

Adolescent males
Thymic masses
NOTCH-1 mutation
Hypercellular marrow with lymphoblasts

A

T cell ALL

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11
Q

Favorable prognostic factors for ALL

A 
Age 2-10
Low WBC count
Hyperdiploidy
Trisomy 4,7,10
T 12;21
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12
Q 
Age ~60 years
Hypogammaglobulinemia
Constitutional symptoms
Hepatosplenomegaly
Lymphadenopathy
Small lymphocytes with SMUDGE CELLS
A

Chronic lymphocytic leukemia

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13
Q

Prognostic factor in CLL that may lead into progression to DLBCL

A

Richter syndrome

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14
Q 
Middle age
Painless generalized lymphadenopathy
BCL 2, t 14;18
Lymphocytosis
Paratrabecular lymphoid aggregates
Indolent course
No cure
A

Follicular lymphoma

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15
Q

60 years old male> female
Rapidly enlarging mass at nodal or extranodal site
BCL6, BCL2, myc
Diffuse pattern of growth, large cells pale to basophilic cytoplasm
Aggressive

A

Diffuse large B cell lymphoma

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16
Q 
Mandibular mass, kidneys, ovaries, adrenals
Latent infection with EBV
MYC gene (t8;14)
Starry sky pattern
Aggressive but responsive to chemo
A

Burkitt Lymphoma

17
Q

Most important plasma cell neoplasm

A

Multiple myeloma

18
Q

65-70 years old
Multiple lytic punched out bone lesions, hypercalcemia, renal failure, dec humoral immunity
PAS positive nuclear (Russell bodies) or cytoplasmic (Ductcher bodies) inclusions

A

Multiple myeloma

19
Q

Most common laboratory findings in Multiple Myeloma

A

M protein
IgG
Hypercalcemia
Bence Jones proteinuria

20
Q

Key cytokine to proliferation and survival in Multiple Myeloma
High levels mean poor prognosis

A

IL-6

21
Q

Naive B cell origin
Small lymphocytes with irregular to occasionally deeply clefted nuclear contours
Painless lymphadenopathy
Poor prognosis

A

Mantle cell lymphoma

22
Q

Memory B cell origin
Arises in tissues on chronic inflammation
Regress when inciting agent removed

A

Marginal zone lymphoma

23
Q

B cell origin
Leukemic cells with fine hairy projections
Splenomegaly, cytopenias
Excellent prognosis

A

Hairy cell leukemia

24
Q

T cell origin
ALK (Ch2) rearrangements
Large anaplastic cells with abundant cytoplasm and horseshoe shaped nucleus
CD 30+ like hodgkin’s

A

Anaplastic large cell lymphoma

25
Q

Cd4 origin
HTLV 1
Cloverleaf cells
Poor prognosis

A

Adult T cell lymphoma

26
Q

Generalized exfoliative erythroderma + leukemia of T cells with cerebriform nuclei

A

Sezary syndrome

Mycosis fungoides

27
Q

Diagnostic of Hodgkin lymphoma
Large, multiple nuclei or single with multiple lobes; each with nucleolus about a size of small lymphocyte
Popcorn cells
Owl eye nuclei

A

Reed- Sternberg cell

28
Q

CD15 CD30 positive
More common ni males except Nodular sclerosis
Adults

A

Hodgkin lymphoma

29
Q

Most common type of Hodgkin lymphoma

A

Nodular sclerosis

30
Q 
T(15;17) 
FAB M3 Best prognosis
Adults
Large myeloblasts with abundant cytoplasm
(+) Auer rods
Rare CNS spread
A

AML

31
Q

Cells with numerous Auer rods in Acute promyelocytic leukemia

A

Faggot cell

32
Q

Adults
BCR ABL t(9;22) Philadelphia chromosome
Hypercellular marrow with abundant green blue wrinkled cytoplasm
Treatment: tyrosine kinase inhibitors

A

CML

33
Q

Proliferativr disorder of dendritic cells
HLA - DR, S-100, CD1a positive
Birbeck granules

A

Langerhans cell histiocytosis

Patho (11 decks)

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