WBC Genes/Markers

Question 1

t(9;22) BCR-ABL

Answer 1

CML

Question 2

Jak2 mutation, LOW EPO, normal paO2

Answer 2

Polycythemia Vera

Question 3

Jak2 mutation, increased megakaryocytes in bone marrow

Answer 3

Essential Thrombocytosis

Question 4

Jak2+ w/ constitutively active tyrosine kinase , HIGH TGF-Beta

Answer 4

Primary Myelofibrosis

Question 5

Del5 and Del7

Answer 5

Myelodysplastic Syndrome

Question 6

t(12;21) fusion of TEL-AML1 (prevents blast differentiation)
OR
t(9;22)

Answer 6

ALL
t(12;21) TEL-AML1 - good prognosis
t(9;22) - poor prognosis

Question 7

Bcl-6 -> ___________
C-MYC -> ___________
Cyclin D1 -> ___________
Bcl-2 -> ___________

Answer 7

Bcl-6 -> inhibits cell checkpoint genes
C-MYC -> cell cycle, transcription
Cyclin D1 -> cell cycle progression
Bcl-2 -> inhibits apoptosis

Question 8

t(3;14) - - BCL6

Answer 8

Diffuse large B-Cell Lymphoma

Question 9

t(8;14) - c-MYC

Answer 9

Burkitt Lymphoma

Question 10

t(11;14) - Cyclin D1

Answer 10

Mantle Cell Lymphoma

Question 11

t(14;18) - BCL2

Answer 11

Follicular Lymphoma

Question 12

Del 11q and 17q, NOTCH1 mutations

Answer 12

CLL

Question 13

t(11;18)

Answer 13

Marginal Zone Lymphoma

Question 14

t(8;21) and t(15;17)

Answer 14

AML

Question 15

t(15;17) PML/RAR-alpha

Answer 15

APML