Histology FINAL Flashcards by Molly Szpakowski

Q

hypochromic, microcytic red cells

A

hypochromic microcytic anemia of iron deficiency

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Q

Ringed Sideroblasts in bone marrow smear - iron in mitochondra

A

Sideroblastic Anemia

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Q

Basophilic Stippling, blood smear w/ ribosomal aggregates and nuclear remnants

A

Sideroblastic Anemia

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Q

Target Cells

A

Beta Thalassemia

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Q

hypersegmented neutrophil w/ 6-lobed nucleus and enlarged RBCs

A

Pernicious Anemia (B12)

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Q

hypersegmented neutrophil w/ 6-lobed nucleus and enlarged RBCs

A

Pernicious Anemia (B12)

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Q

spherocytes (no central pallor),

A

Hereditary Spherocytosis

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Q

elliptocytes, defect of rBC membrane cytoskeleton proteins (Spectrin)

A

Hereditary Elliptocytosis

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Q

low magnification shows sickle cells, and anisocytosis

A

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Q

HbC crystals on blood smear, target cells

A

Hemoglobin C

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Q

A

Warm agglutinin w/ spherocytes

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Q

A

RBC cold agglutination

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Q

Heinz bodies (denatured hemobglobin) and Bite Cells (splenic macrophages remove the heinz body inclusion s)

A

G6PD Deficiency

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Q

Schistocytes and helmet cells

A

Microangiopathic Hemolytic Anemia

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Q

Schistocytes and helmet cells

A

Microangiopathic Hemolytic Anemia

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Q

bone marrow: predominantly fat and few bone spicules

A

Aplastic Anemia

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Q

tear drop cells (dacrocytes)

A

Myelopthisic Anemia

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Q

replacement by tumor

A

Myelopthisic Anemia

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Q

bone marrow replaced w/ immature myeloid precursors

A

Acute Myeloid Leukemia

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Q

Auer rods (composed of MPO) seen in cytoplasm of myeloid leukemic blasts

A

Acute Myeloid Leukemia

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Q

lots of larger azurophilic granules in cytoplasm

A

APML (M3)

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Q

increased granulocytic precursors

A

CML

Q

increased platelets

A

Essential Thrombocytosis

Q

bone marrow: increased megakaryocytes

A

Essential Thrombocytosis

bone marrow - hypercellular, dysplastic cells in marrow and blood

MDS Morphology

bone marrow - ringed sideroblasts

MDS Morphology

condensed nuclear chromatin, small nucleoli, and scant granular cytoplasm, No granules or Aurer rods

Acute Lymphoblastic Anemia

replacement of bone marrow

Acute Lymphoblastic Anemia

Monomorphic lymphocytes, scant cytoplasm, Smudge Cells

Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma

large cells with large nuclei containing prominent nucleoli, mitotic figures

Diffuse Large B-Cell Lymphoma

obliterated lymph note architecture

Diffuse Large B-Cell Lymphoma

multiple uniform germinal centers/follicles

Follicular Lymphoma

angulated cleaving of nuclei (folding or grooving)

Follicular Lymphoma

tingible body macrophages, heterogeneous cell population

Follicular Hyperplasia

germinal center Bcl-2 positive

Follicular Lymphoma

composed of small round irregular lymphocytes resembling those seen in the marginal zone of myphoid follicles

MALToma

starry-sky pattern due to tingable body macrophages

Burkitt Lymphoma

large nucliei w/ multiple small nucleoli, High Ki-67 Index

Burkitt Lymphoma

Reed Sternberg

Hodgkin Lymphoma

lacunar variant

Nodular Sclerosing

Popcorn cell variant

Nodular Lymphocyte Predominant H.L.

Hair-like projections of cytoplasm

Hairy Cell Leukemia

TRAP (+)

Hair Cell Leukemia

rouleaux formation of RBCs

Plasma Cell Neoplasms

Plasma cells with fried egg appearance

Multiple Myeloma

Plasmacytoid cells - fried egg

Waldenstrom Macroglobulinemia

Dutcher bodies - inclusions of immunoglobulins in nucleus of atypical plasma cells

Waldenstrom Macroglobulinemia

Russell bodies - inclusions of immunoglobulins in cytoplasm of atypical plasma cells

Waldenstrom Macroglobulinemia

skin pautrier's microabscess

Mycoses Fungoides

cerebriform nuclei

Sezary Syndrome

multi-lobed (cloverleaf) cells

ATLL

Horseshoe shaped Hallmark Cells

Anaplastic Large Cell Lymphoma