Histology FINAL Flashcards by Molly Szpakowski

Q

hypochromic, microcytic red cells

A

hypochromic microcytic anemia of iron deficiency

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Q

Ringed Sideroblasts in bone marrow smear - iron in mitochondra

A

Sideroblastic Anemia

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Q

Basophilic Stippling, blood smear w/ ribosomal aggregates and nuclear remnants

A

Sideroblastic Anemia

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Q

Target Cells

A

Beta Thalassemia

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Q

hypersegmented neutrophil w/ 6-lobed nucleus and enlarged RBCs

A

Pernicious Anemia (B12)

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Q

hypersegmented neutrophil w/ 6-lobed nucleus and enlarged RBCs

A

Pernicious Anemia (B12)

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Q

spherocytes (no central pallor),

A

Hereditary Spherocytosis

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Q

elliptocytes, defect of rBC membrane cytoskeleton proteins (Spectrin)

A

Hereditary Elliptocytosis

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Q

low magnification shows sickle cells, and anisocytosis

A

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Q

HbC crystals on blood smear, target cells

A

Hemoglobin C

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Q

A

Warm agglutinin w/ spherocytes

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Q

A

RBC cold agglutination

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Q

Heinz bodies (denatured hemobglobin) and Bite Cells (splenic macrophages remove the heinz body inclusion s)

A

G6PD Deficiency

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Q

Schistocytes and helmet cells

A

Microangiopathic Hemolytic Anemia

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Q

Schistocytes and helmet cells

A

Microangiopathic Hemolytic Anemia

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Q

bone marrow: predominantly fat and few bone spicules

A

Aplastic Anemia

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Q

tear drop cells (dacrocytes)

A

Myelopthisic Anemia

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Q

replacement by tumor

A

Myelopthisic Anemia

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Q

bone marrow replaced w/ immature myeloid precursors

A

Acute Myeloid Leukemia

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Q

Auer rods (composed of MPO) seen in cytoplasm of myeloid leukemic blasts

A

Acute Myeloid Leukemia

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Q

lots of larger azurophilic granules in cytoplasm

A

APML (M3)

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Q

increased granulocytic precursors

A

CML

Q

increased platelets

A

Essential Thrombocytosis

Q

bone marrow: increased megakaryocytes

A

Essential Thrombocytosis

Q

bone marrow - hypercellular, dysplastic cells in marrow and blood

A

MDS Morphology

Q

bone marrow - ringed sideroblasts

A

MDS Morphology

Q

condensed nuclear chromatin, small nucleoli, and scant granular cytoplasm, No granules or Aurer rods

A

Acute Lymphoblastic Anemia

Q

replacement of bone marrow

A

Acute Lymphoblastic Anemia

Q

Monomorphic lymphocytes, scant cytoplasm, Smudge Cells

A

Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma

Q

large cells with large nuclei containing prominent nucleoli, mitotic figures

A

Diffuse Large B-Cell Lymphoma

Q

obliterated lymph note architecture

A

Diffuse Large B-Cell Lymphoma

Q

multiple uniform germinal centers/follicles

A

Follicular Lymphoma

Q

angulated cleaving of nuclei (folding or grooving)

A

Follicular Lymphoma

Q

tingible body macrophages, heterogeneous cell population

A

Follicular Hyperplasia

Q

germinal center Bcl-2 positive

A

Follicular Lymphoma

Q

composed of small round irregular lymphocytes resembling those seen in the marginal zone of myphoid follicles

A

MALToma

Q

starry-sky pattern due to tingable body macrophages

A

Burkitt Lymphoma

Q

large nucliei w/ multiple small nucleoli, High Ki-67 Index

A

Burkitt Lymphoma

Q

Reed Sternberg

A

Hodgkin Lymphoma

Q

lacunar variant

A

Nodular Sclerosing

Q

Popcorn cell variant

A

Nodular Lymphocyte Predominant H.L.

Q

Hair-like projections of cytoplasm

A

Hairy Cell Leukemia

Q

TRAP (+)

A

Hair Cell Leukemia

Q

rouleaux formation of RBCs

A

Plasma Cell Neoplasms

Q

Plasma cells with fried egg appearance

A

Multiple Myeloma

Q

Plasmacytoid cells - fried egg

A

Waldenstrom Macroglobulinemia

Q

Dutcher bodies - inclusions of immunoglobulins in nucleus of atypical plasma cells

A

Waldenstrom Macroglobulinemia

Q

Russell bodies - inclusions of immunoglobulins in cytoplasm of atypical plasma cells

A

Waldenstrom Macroglobulinemia

Q

skin pautrier’s microabscess

A

Mycoses Fungoides

Q

cerebriform nuclei

A

Sezary Syndrome

Q

multi-lobed (cloverleaf) cells

A

ATLL

Q

Horseshoe shaped Hallmark Cells

A

Anaplastic Large Cell Lymphoma

Q

A

Q

A