Antivirals

Question 1

Bictegravir

Answer 1

Target: Integrase

Blocks integration of viral DNA into host genome

Question 2

Darunavir

Answer 2

Target: Protease Inhibitor

prevents cleavage of polyproteins necessary for maturation of infectious viral particles

Question 3

Doravirine

Answer 3

Target: NNRTI

allosteric inhibitor of Reverse Transcriptase

Question 4

Enfuviritide

Answer 4

Target: gp41

inhibits fusion of HIV envelope w/ host cell membrane

Question 5

Ibalizumab

Answer 5

Target: CD4

blocks conformational changes needed for CCR5 binding

Question 6

Zidovudine

Answer 6

Target: NRTI

competitive inhibitor on Reverse Transcriptase

Question 7

Lenacapavir

Answer 7

Target: Capsid

disrupt nuclear transport & capsid assembly, leads to inhibited replication

Question 8

Ritonavir

Answer 8

Target: CYP3A4

Booster

Question 9

Fostemsavir

Answer 9

Target: gp120

prevents HIV from binding to CD4 receptor on host cells

Question 10

Maraviroc

Answer 10

Target: CCR5

prevents gp120 binding, required for HIV entry and fusion

Resistance due to chemokine tropism shift or viral gp120 mutation

Question 11

Initial ART Regimen

Answer 11

One integrase inhibitor + two NRTIs

Question 12

Alternative ART Regimen

Answer 12

Two NRTIs + One Protease Inhibitor + Booster