RBCs

Question 1

Microcytic Anemias

Answer 1

Alpha thalassemia
Beta thalassemia
Anemia of Chronic disease
SiDeroblastic
Iron (FE) deficiency
Lead Poisoning

ABCDE…lead poisoning

Question 2

Macrocytic Anemias

Answer 2

B12 Deficiency (Pernicious Anemia)
Folate Deficiency
Drug
Alcoholic Liver Disease
Reticulocytosis

Question 3

Normocytic Anemias

Answer 3

Extravascular: Hereditary spherocytosis, sickle cell, thalassemias

Intravascular: G6PD deficiency, Paroxysmal Nocturnal Hemoglobin, Malaria, Hemolytic disease of newborn

Decreased Production: aplastic anemia, myelophthisic, anemia of chronic disease, renal failure

Question 4

Reticulocytosis is normal in anemia EXCEPT if

Answer 4

vitamin deficient, iron deficient or chronic disease

Question 5

Low O2 triggers release of ______ from kidneys, which increases _______ in peripheral blood

Answer 5

Low O2 triggers release of erythropoietin from kidneys, which increases reticulocytes in peripheral blood

Question 6

Hepcidin

Answer 6

• limits iron transfer from macrophages to erythroid precursors
• suppresses erythropoietin
• increases iron in storage

Question 7

When body iron stores decrease or when erythropoiesis is stimulated plasma ______ levels fall and _____ activity increases

Answer 7

When body iron stores decrease or when erythropoiesis is stimulated plasma hepcidin levels fall and ferroportin activity increases