wbc disorders dsa Flashcards
1
Q
primary causes of leukocytosis
A
- hereditary neutrophilia
- chronic idiopathic neutrophilia
- pelger-Huet anomaly
- Down syndrome
- familial cord urticaria
- CML and other myeloproliferative disorders
- post-splenectomy
2
Q
secondary causes of leukocytosis
A
- infection
- chronic infl
- cigarette smoking
- stress
- drug induced- corticosteroids
- nonhematologic malignancy
- marrow stimulation
3
Q
general evaluation of a pts with neutrophilia
A
- repeat counts
- examine smear:
- if leukoerythroblastic- bone marrow examination
- if not- fever/infection signs, drugs, smoker
4
Q
neutrophilia- if leukoerythroblastic- dx?
A
tumor
- CML
- non-CML MPN (P vera, myelofibrosis)
5
Q
neutrophilia- if not leukoerythroblastic- dx?
A
- autoimmune
- myeloproliferative
- drug induced
- smoking related
- idiopathic
6
Q
primary causes of neutropenia
A
- ethnic and benign familial (constitutional)
- severe congenital
- cyclic
- other congenital syndromes
7
Q
secondary causes of neutropenia
A
- infection-related
- drug-induced and due to marrow injury
- immune
- inc margination and hypersplenism
- nutritional def
- chronic idiopathic
