Lymphomas chpt 13, 39 dsa Flashcards
1
Q
Non-Hodgkin Lymphomas- essentials of dx
A
- painless lymphadenopathy
- pathologic diagnosis of lymphoma is made by pathologic examination of tissue
2
Q
Burkitt lymphoma- cytogenetics
A
-MYC- chrom 8 and 14
3
Q
Follicular lymphoma- cytogenetics
A
-t(14;18)- BCL-2 is overexpressed- protection against apoptosis
4
Q
NHL- sx and signs
A
- lymphadenopathy
- usually disseminated at time of dx
- B sx’s- fever, drenching night sweats, weight loss >10%
5
Q
NHL- lab findings
A
- bone marrow involvement- paratrabecular monoclonal lymphoid aggregates
- dx- tissue biopsy of LN!!
6
Q
Indolent lymphomas
A
- follicular lymphomas
- marginal zone lymphomas
- CLL
- tx depends on stage and clinical status of pt
7
Q
indolent lymphomas- tx
A
- localized irradiation- in pts with limited dz and 1 or 2 contiguous LNs
- if disseminated- not curable
- rituximab
8
Q
Aggressive lymphomas- tx
A
- diffuse large B-cell lymphoma
- mantle cell lymphoma
- high grade lymphoma
- peripheral T-cell lymphomas
9
Q
diffuse large B-cell lymphoma- tx
A
- localized dz- short-course immunochemotherapy (R-CHOP) and localized radiation
- advanced dz- 6 cycles of immunochemotherapy (R-CHOP)
10
Q
Gastric lymphoma
A
- primary lymphoma- 95% are of non-hodgkin B cell lymphomas- arise from MALT
- H pylori- risk factor
11
Q
Hodgkin lymphoma- essentials of dx
A
- painless lymphadenopathy
- constitutional sx’s may or may not be present
- pathologic dx by LN biopsy
12
Q
HL- clinical findings
A
- bimodal age (20s and 50s)
- painless mass in neck
- constitutional sx’s
13
Q
HL- Ann Arbor staging
A
- 1- 1 LN region
- 2- 2 or more LN regions on 1 side of diaphragm
- 3- LN regions on both sides of diaphragm
- 4- disseminated dz with extranodal involvement
- A- lack constitutional sx’s
- B- weight loss, fever, or drenching night sweats
14
Q
HL- tx
A
-ABVD- first line
