Plasma cell disorders CIS Flashcards
1
Q
Plasma cell disorders- are what?
A
- clonal prolif and immortalization of immunoglobulin-secreting plasma cells
- hallmark- isolated peak in the GAMMA region on serum protein electrophoresis representing a single immunoglobulin molecule (M-protein)
2
Q
Plasma cell disorders- in who? presenting complaints?
A
- middle-aged/older
- heavy chain dz- in any age group
- fatigue, weight loss, bone pain, infection
- bones are brittle!
- hyperviscosity in macroglobulinemia- rare with other disorders
3
Q
if A:G ratio < 1 (albumin:globulin)- diff dx?
A
-plasma cell disorder!!!
4
Q
MUGS- what spike?
A
Y (gamma) globulin spike
5
Q
solitary plasmacytoma- tx?
A
radiation
6
Q
MM- staging how? dx?
A
- skeletal xray survey!! (cant use a bone scan)
- dx- BM biopsy- marrow plasma cells > 10% and abnormal looking!!!
7
Q
MM- tx?
A
- bisphosphonates (for hypercalcemia and preventing bone resorption)
- floradimide, dexamethasone, protease inhibitors
8
Q
hyperviscosity- fundoscopy?
A
sause linking!!
9
Q
what can cause hyperviscosity?
A
- waldenstrom’s macroglobulinemia
- polycythemia vera
10
Q
waldenstrom’s macroglobulinemia- tx?
A
-plasmapheresis for hyperviscosity
