WBC Flashcards
Neutropenia
Chemotherapy
LEUKOPENIA
Radiation
Basophilia
CML
Eosinophilia
Hodgkins lymphoma-Mixed cellularity
Lymphocytic leukocytosis
Viral infection
Bordetella peruses infection
Monospot test
Heterophile antibody
Infectious mononucleosis
pharyngitis
Hepatitis with hepatomegaly
gen lymphadenopathy
splenomegaly
rash with ampicillin
Cells with TdT positive and CD10,19,20
B ALL
t(12:21) - children
t(9:22) - adults poor prognosis
Cells with TdT positive and CD2 to CD8
T ALL
cells with Myeloperoxidase staining
Myeloblast
Absent in monoblast and Megakaryoblast
t(15:17) with DIC
Acute promyelocytic leukemia
Cells with CD5 and CD20
naive B cell
CLL
m/c
gen lymphadenopathy
older adults
Complication
Hypogammaglobulinemia-infections
Autoimmune hemolytic anemia IgG warm agglutinin
Richter transformation- B cell lymphoma
TRAP positive[Tartarate resistant acid phosphatase]
with Bone marrow fibrosis
Hairy cell leukemia
Mature B cell
spleenomagaly
NO LYMPHADENOPATHY
Rash,
gen lymphadenopathy
spleenomagaly
lytic bone lesions with hypercalcemia
Adult T cell leukemia- Mature CD4 T cell
Ass with HTLV-1
Neoplastic T cell in epidermiis
Pautrier microabcess
Mycosis Fungoides - Mature CD4 T cell
spreads to blood- Sezary syndrome-Lymphocytes with
cerebriform nucleus-sezary cell
Basophils increased
t(9:22)
Spleenomagaly
Negative Leukocyte Alkaline phosphatase[LAP]
CML
JAK 2 kinase mutation
Polycythemia vera-RBC
Essential thrombocythemia-Platelets
spleenomagaly with Tear drop RBC
Myelofibrosis
neoplastic proliferation of megakaryocytes—incraesed PDGF-Marrow fibrosis
Nucleated RBC,Tear drop RBC
Painless lymphadenopathy
late adulthood
neoplastic proliferation of lymphoid cells
Non Hodgkin lymphoma -Extranodal -leukemic phase occur small B cell-Follicular,Mantle ,marginal intermediate-burkett large-diffuse
Painless lymphadenopathy
young adult
neoplastic proliferation of Reed Sternberg cell
Hodgkin lymphoma
with B symptom-fever,malaise,night sweat
rarely extra nodal
Radiotherapy
CD 20
t(14:18)
over expression of BCL2
Follicular lymphoma
-monoclonal
lack of tangible body macrophages
CD 20
t(11:14)
over expression of cyclin D
Mantle lymphoma
CD 20
ass with Hashimoto
sjogren
H pylori Malt lymphoma
Marginal lymphoma
CD 20 with EBV
t(8:14)
C MYC
Burkitt lymphome
STARY SKY appearance
RS cell
OWL eyed nuclei -large B cell with multi lobed nuclei with prominent nucleoli
Hodgkins -Nodular sclerosis- m/c Lymphocyte rich-good prog Mixed cellularity-eosinophilia lymphocyte depleted-poor, HIV positive
neoplastic proliferation of plasma cells
Lytic bone lesion
elevated sr.protein
Multiple myeloma -High IL 6 M spike - monoclonal IgG and IgA infection is cause of death-monoclonal so no effect Rouleux formation of RBC Primary amyloidosis Bence Jones prteinuria-Renal failure
Increase M spike
without lytic bone, amyloidosis,bence jones
Monoclonal gamapathy of Undetermined significance
Increased M spike -IgM
Waldenstrom macroglobinemia
-hyperviscosity-visual or neurological defects
bleeding
neoplastic proliferation of langerhans cells[dendritic cell in skin]
birbeck granules[tennis racket]
S 100 +
CD1a+
Langerhans cell histiocytosis
types
Letterer siwe disease- infants skin rash, cystic skeletal defect, fatal
Eosinophilic granuloma-adolosecent with pathological fracture, no skin lesion
Hand sculler christian disease-Scalp rash, exophthalmus in children, diabetes insipidus,lytic skull defect
