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Pathology > WBC > Flashcards

WBC Flashcards

1
Q

Neutropenia

A

Chemotherapy

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2
Q

LEUKOPENIA

A

Radiation

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3
Q

Basophilia

A

CML

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4
Q

Eosinophilia

A

Hodgkins lymphoma-Mixed cellularity

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5
Q

Lymphocytic leukocytosis

A

Viral infection

Bordetella peruses infection

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6
Q

Monospot test

Heterophile antibody

A

Infectious mononucleosis

pharyngitis
Hepatitis with hepatomegaly
gen lymphadenopathy
splenomegaly

rash with ampicillin

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7
Q

Cells with TdT positive and CD10,19,20

A

B ALL

t(12:21) - children
t(9:22) - adults poor prognosis

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8
Q

Cells with TdT positive and CD2 to CD8

A

T ALL

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9
Q

cells with Myeloperoxidase staining

A

Myeloblast

Absent in monoblast and Megakaryoblast

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10
Q

t(15:17) with DIC

A

Acute promyelocytic leukemia

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11
Q

Cells with CD5 and CD20

naive B cell

A

CLL
m/c
gen lymphadenopathy
older adults

Complication
Hypogammaglobulinemia-infections
Autoimmune hemolytic anemia IgG warm agglutinin
Richter transformation- B cell lymphoma

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12
Q

TRAP positive[Tartarate resistant acid phosphatase]

with Bone marrow fibrosis

A

Hairy cell leukemia
Mature B cell
spleenomagaly
NO LYMPHADENOPATHY

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13
Q

Rash,
gen lymphadenopathy
spleenomagaly
lytic bone lesions with hypercalcemia

A

Adult T cell leukemia- Mature CD4 T cell

Ass with HTLV-1

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14
Q

Neoplastic T cell in epidermiis

A

Pautrier microabcess
Mycosis Fungoides - Mature CD4 T cell
spreads to blood- Sezary syndrome-Lymphocytes with
cerebriform nucleus-sezary cell

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15
Q

Basophils increased
t(9:22)
Spleenomagaly
Negative Leukocyte Alkaline phosphatase[LAP]

A

CML

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16
Q

JAK 2 kinase mutation

A

Polycythemia vera-RBC

Essential thrombocythemia-Platelets

17
Q

spleenomagaly with Tear drop RBC

A

Myelofibrosis
neoplastic proliferation of megakaryocytes—incraesed PDGF-Marrow fibrosis

Nucleated RBC,Tear drop RBC

18
Q

Painless lymphadenopathy
late adulthood
neoplastic proliferation of lymphoid cells

A 
Non Hodgkin lymphoma
-Extranodal
-leukemic phase occur
small B cell-Follicular,Mantle ,marginal
intermediate-burkett
large-diffuse
19
Q

Painless lymphadenopathy
young adult
neoplastic proliferation of Reed Sternberg cell

A

Hodgkin lymphoma
with B symptom-fever,malaise,night sweat
rarely extra nodal

Radiotherapy

20
Q

CD 20
t(14:18)
over expression of BCL2

A

Follicular lymphoma
-monoclonal
lack of tangible body macrophages

21
Q

CD 20
t(11:14)
over expression of cyclin D

A

Mantle lymphoma

22
Q

CD 20
ass with Hashimoto
sjogren
H pylori Malt lymphoma

A

Marginal lymphoma

23
Q

CD 20 with EBV
t(8:14)
C MYC

A

Burkitt lymphome

STARY SKY appearance

24
Q

RS cell

OWL eyed nuclei -large B cell with multi lobed nuclei with prominent nucleoli

A 
Hodgkins
-Nodular sclerosis- m/c
 Lymphocyte rich-good prog
 Mixed cellularity-eosinophilia
 lymphocyte depleted-poor, HIV positive
25
Q

neoplastic proliferation of plasma cells
Lytic bone lesion
elevated sr.protein

A 
Multiple myeloma
-High IL 6
 M spike - monoclonal IgG and IgA
 infection is cause of death-monoclonal so no effect
 Rouleux formation of RBC
 Primary amyloidosis
 Bence Jones prteinuria-Renal failure
26
Q

Increase M spike

without lytic bone, amyloidosis,bence jones

A

Monoclonal gamapathy of Undetermined significance

27
Q

Increased M spike -IgM

A

Waldenstrom macroglobinemia
-hyperviscosity-visual or neurological defects
bleeding

28
Q

neoplastic proliferation of langerhans cells[dendritic cell in skin]
birbeck granules[tennis racket]
S 100 +
CD1a+

A

Langerhans cell histiocytosis
types
Letterer siwe disease- infants skin rash, cystic skeletal defect, fatal
Eosinophilic granuloma-adolosecent with pathological fracture, no skin lesion
Hand sculler christian disease-Scalp rash, exophthalmus in children, diabetes insipidus,lytic skull defect

Pathology (10 decks)

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