RBC Flashcards
lab of Iron defn
dec sr iron
dec % saturation
dec ferritin ,inc TIBC
Lab of anemia of chronic disease
dec sr iron
dec % saturation
inc ferritin ,dec TIBC
Lab of sideroblastic anemia
inc sr iron inc % saturation inc ferritin ,dec TIBC causes B6 defn,ALA synthetase defn lead poisoning alcoholism
Alpha thalassemia
Chr 16 -four genes]
three genes mutation-HbH
Four gene - Hb bars -Gamma chain aggregate
beta thalassemia
Minor
Target cells
HbA2- 5%
HbF - 2%
HbA -93%
Major
Target cell
‘Nucleated RBC
HbA2 and HbF
No HbA
Subacute combined degeneration of spinal cord
Vit B 12 defn
post column [loss of vibration and proprioception]and lat cotico spinal tract [spastic paresis]
Anemia
spleenomagaly
jaundice
bilirubin stone
Extravascular hemolysis
corrected Reticulocyte - >3%
defect in RBC membrane protein
Herd spherocytosis
Ankyrin,spectrin,band 3
spherocytes
long term Pain crisis
Sickle cell anemia Dactylitis-swelling of hand and feet in infants acute chest syndrome-cause of death Renal papillary necrosis Hbs -90% HbF -8% HbA2 -2%
Microscopic hematuria
Sickle cell trait
IgA nephropathy
Infective endocarditis
sickle cell triat
HbA 55%
HbS 43%
HbA2 2%
HbA2(alpha 2 and delta 2)
diff between thalassemia minor and sickle cell
sickle cell -2% (2- S)
that minor -5%
Loss of Decay accelerating factor
absent Glycosyl phosphatidyl Inositol
Paroxysmal nocturnal hemoglobinuria
intravascular hemolysis
IgG mediated immune hemolytic anemia-warm agglutinin
extravascular hemolysis
SLE
CLL
drugs-Penicillin,cephalosporin
IgM mediated immune hemolytic anemia-cold agglutinin
intravascular hemolysis
Mycoplasma pneumonia
Infectious mononucleosis
