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Hematology > WBC > Flashcards

WBC Flashcards

1
Q

Predominant WBC in adults

A

Neutrophil

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2
Q

Predominant WBC in children <=4 year of age

A

Lymphocyte

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3
Q

On dtermining WBC maturity, MOST valuable and reliable criterion is

A

Nuclear chromatin patter

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4
Q

Earliest recognizable granulocytic precursor using light microscopy

A

Myeloblast

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5
Q

shows the presence of dispersed Primary Azurophilic granules in the cytoplasm, the number of granules does NOT exceed 20 per cell

A

Type II myeloblast

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6
Q

larger than Myeloblast, ‘‘hof’’ is usually seen in normal promyelocyte, full of primary azurophilic/nonspecific granules

A

Promyelocyte

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7
Q

Hollow in the cytoplasm of a cell that lodges the nucleus

A

Hof

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8
Q

LAst stage capable of mitosis; stage of synthesis of secondary granules (specific granules)

A

Myelocyte

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9
Q

may look very similar to the promyelocyte

A

Early myelocyte

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10
Q

patches of grainy pale pink cytoplasm representing secondary granules start to become obvious in the area of the Golgi apparatus

A

Dawn of Neutrophilia

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11
Q

Nucleoli are absent. Synthesis of Tertiary granules
Juvenile cell
First stage of Nuclear indentation

A

Metamyelocyte

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12
Q

Stab cell or Staff cell. Youngest granulocytic to normally appear in Per. Blood
Secretory granules may begin to form

A

Band cell

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13
Q

Tertiary granules is also known as

A

Gelatinase

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14
Q

usually caused by a shift of marginated cells to the circulatory pool

A

Pseudoneutrophilia

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15
Q

associated with drugs: amidopyrine and cephalosporin. aka. Extreme Neutropenia

A

Agranulocytosis

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16
Q

caused by T. spiralis, possibly produced the highest eosinophil count

A

Trichinosis

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17
Q

Associated conditions in Basophilia
‘’ I H U E’’

A

Immediate hypersensitivity rxn
Hypothyroidism
Ulcerative colitis
Estrogen theraphy

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18
Q

predominant type of Lymphocyte in normal adult blood
composed mostly of nucleus
scanty cytoplasm

A

Small lymphocyte

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19
Q

final maturation stage of B lymphocyte
‘‘tortoise shell’’, ‘‘cartwheel’’ or ‘‘clock-face’’

A

Plasma cell

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20
Q

may contain round discrete globules called Russel bodies
‘‘dark-blue’‘/sea-blue/ cornflower in color

A

Cytoplasm of Plasma cell

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21
Q

most common malignant disease of plasma cells

A

Plasma cell myeloma

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22
Q

Functions of macrophage
‘’ P S R P’’

A

Phagocytosis
Synthesis of Nitric oxide
Release of IL-1
Produce transcobalamin

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23
Q

Mesanglial cells (Renal macrophage)

A

Kidneys

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24
Q

Dendritic cells

A

Lymph nodes

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25
Q

Type A cells

A

Synovial tissue

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26
Q

Microglial cells

A

Brain

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27
Q

Most common WBC in the normal peripheral blood, first to reach the infected areas then Monocyte

A

Neutrophil

28
Q

neutrophil move in what manner

A

Zigzag

29
Q

Neutrophils share a common progenitor with monocytes

A

GMP (Granulocyte Monocyte Progenitor)

30
Q

Major stimulatory cytokine for neutrophil production

A

G-CSF
Granulocyte-Colony Stimulating Factor

31
Q

Half life of neutrophils in the blood

A

7 hours

32
Q

extracellular threadlike structures thought to represent chains of nucleosome from unfolded nuclear chromatin material

A

NETs

33
Q

3 major function of Neutrophil

A
  1. Phagocytosis
  2. Generation of NETs
  3. Secretory function
34
Q

an enzyme that exhibits bactericidal, fungicidal and viricidal properties

A

Myeloperoxidase

35
Q

aka. Muramidase an anti-microbial enzyme

A

Lysozyme

36
Q

an iron binding protein that competes w/ bacteria for Iron

A

Lactoferrin

37
Q

contribute to tight stationary binding between neutro and endothelial cells

A

CD11b/ CD18

38
Q

Neutrophil is the only WBC that has an activity with the enzyme

A

Alkaline phosphatase

39
Q

Most specific cytokine for Eosinophilic Lineage

A

IL-5

40
Q

hallmark of allergic disorders

A

Eosinophilia

41
Q

Circulating half life of Eosinophil

A

18 hours

42
Q

Survival time of eosinophils in human tissue ranges from

A

2 to 5 days

43
Q

disintegration products of eosinophils, hexagonal, bipyramidal crystals

A

Charcot-leyden Crystals

44
Q

Color of Charcot-Leyden crustals in Hematoxylin

A

Black

45
Q

Color of Charcot-Leyden crystals in Eosin

A

Red

46
Q

Color of Charcot-Leyden crystals in Trichome stain

A

Purplish red

47
Q

Formed during the Promyelocyte stage, last to be released during exocytosis

A

Primary (Azurophilic) Granules

48
Q

Formed during the Myelocyte and Metamyelocyte stages, Third to be released

A

Scondary (Specific) Granules

49
Q

Formed during the Metamyelocyte and Band stages, Second to be released

A

Tertiary (Gelatinase) Granules

50
Q

Formed during the Band and Segmented neutrophil stages, First to be released

A

Secretory Granules

51
Q

Formed during the Promyelocyte stage. Contain Charcot-Leyden Crystal protein

A

Primary Eosinophil Granules

52
Q

Formed througout the remaining maturation of Eosinophil

A

Secondary granules

53
Q

happens whene xtracellular intact granules are deposited during cell lysis

A

Cytolysis

54
Q

secretory vesicles remove specific proteins from secondary granules, travel to Plasma membrane fuse and empty proteins into extracellular space

A

Piecemeal degranulation

55
Q

granules fuse together within the eosinophil prior to fusing with the plasma membrane

A

Compound exocytosis

56
Q

Basophil Granules
‘’ H I C I’’

A

Histamine
Interleukin-4
Chondroitin sulfates
Interleukin-13

57
Q

a dye that can bind with acid mucopolysaccharides ain blood cells to form metachromatic complexes

A

Toluidine blue

58
Q

histochemically defined as a reaction product color that is considerably different from the color of the dye itself

A

Metachromasia

59
Q

valuable in identifying basophil and mast cells

A

Toluidine blue stain

60
Q

Lifespan of Basophil

A

60 hrs

61
Q

round horse-shoe shaped or lobulated
Chromatin: lace-like or stringy
vacuoles present

A

Monocyte

62
Q

Cytoplasm (Monocyte):abundant blue-gray containing fine indistinct granules called

A

Azure dust (ground-glass appearance)

63
Q

Monocyte are best identified by their strong positive reaction with

A

Nonspecific Esterase stain

64
Q

Monocyte are said to be rich in

A

Muramidase

65
Q

Monocyte remain in the circulation roughly

A

3 days

Hematology (9 decks)

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