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Hematology > Anemia > Flashcards

Anemia Flashcards

1
Q

Not a disease defined as the decrease below normal or one or more

A

Anemia

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2
Q

rare but potentially deadly bone marrow failure syndrome

A

Aplastic anemia

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3
Q

most frequently implicated drug in aplastic anemia

A

Chloramphenicol

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4
Q

asso. w/ identified cause, some of the causes include chemicals and viruses/ drugs

A

Secondary Acquired Aplastic Anemia

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5
Q

most common of the inherited aplastic anemia

A

Fanconi Anemia

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6
Q

What are the physicl abnormalities include in Fanconi Anemia

A

Skeletal Abnormalities
Skin pigmentation
Short stature
Abn. eyes, kidney and genitals

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7
Q

Hyperpigmentation, Hypopigmentation, cAFE-AU-LAIT LESIONS

A

Physical abnormalities in Fanconi anemia asso. w. skin pigmentation

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8
Q

Thumb malformation, Microcephaly, Scoliosis

A

Physical abnormalities in Fanconi anemia: Skeletal abn.

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9
Q

PNH is also known as

A

Marchifava-Micheli Syndrome

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10
Q

It is caused by deficiency of DAF (CD 55) and MIRL (CD 59)

A

PNH

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11
Q

Confirmatory test for PNH

A

Flow cytometry

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12
Q

Tests for PNH

A

Ham’s Acidified Serum Test
Sugar water Test
Flow Cytometry

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13
Q

examples of complementary regulatory proteins

A

DAF
Membrane Inhibitor of Reactive Lysis (MIRL)

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14
Q

Most common anemia among hospitalized patients, Ass. w/ chronic infxn, body store have abundant Iron

A

Anemia of Chronic Inflammation

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15
Q

Central feature of ACI

A

Sideropenia (Decreased serum iron)

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16
Q

Acute phase reactants that contribute to ACI

A

Hepcidin
Ferritin
Lactoferrin

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17
Q

Master regulatory hormone for systemic iron metabollism inactivates FERROPORTIN

A

Hepcidin

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18
Q

Transport iron from Tissue to the Blood

A

Ferroportin

19
Q

develop when the production of Protoporphyrin or the incorporation of iron into Protoporphyrin is Prevented; iron is trapped in the Mitochondria

A

Sideroblastic Anemia

20
Q

NCULEATED RBC precursor w/ Cytoplasmic Iron Granules

A

Sideroblast

21
Q

ANucleate RBC w/ Iron granules

A

Siderocyte

22
Q

ANucleate RBC w/ Iron granules

A

Siderocyte

23
Q

Hallmark of the Sideroblastic Anemia

A

Ring Sideroblasts

24
Q

Most common anemia, caused by Blood loss/ Nutitional def/ ^ iron demands/ Malignancies of GI tract/ Hookworm Infxn

A

IDA

25
Q

spooning of the fingernails

A

Koilonychia

26
Q

cravings for non-food items

A

Pica

27
Q

craving for ICE

A

Pagophagia

28
Q

indirectly measures the conc. of transferrin by measuring its ability to bind iron

A

TIBC

29
Q

the first laboratory test to become abnormalwhen iron stores begin to decline; revelas the body’s tissue iron stores

A

Serum Ferritin

30
Q

caused by the lack of intrinsic factor

A

V B12 deficiency

31
Q

Found in the stomach produce HCI and IF

A

Parietal cells

32
Q

a type of megaloblastic anemia caused by inadequate intake, Increased need, renal dialysis

A

Folate deficiency

33
Q

Considered as the root cause of megaloblastic anemia

A

Impaired DNA synthesis

34
Q

DNA synthesis is dependent on an important structure called

A

Thymidine Triphosphate (TTP)

35
Q

VB12 is also known as

A

Cobalamin

36
Q

Synthetic form of VB12 found only in supplements

A

Cyanocobalamin

37
Q

naturally occuring form that may be obtained from either food sources or supplements

A

Methylcobalamin

38
Q

loss of epithelium on the tongue results in a smooth surface and soreness

A

Glossitis

39
Q

Laboratory test that differentiate Folate def. and VB12 Def.

A

holoTC assay

40
Q

Other possible findings in megaloblastic anemia
‘‘TNBCH’’

A

Teardrop cells
Nucleated RBCs
Howell-Jolly bodies
Basophilic Stippling
Cabot rings

41
Q

Metabolically active form of VB12

A

Holotrancobalamin

42
Q

Disorders characterized by impaired synthesis of HEME, example: LEAD POISONING

A

Porphyrias

43
Q

LEAD can inhibit enzymes in the body including

A

Ferrocheletase adn Pyrimidine-5-Nucleotidase

44
Q

enzyme needed to completely remove the RNA remnants from reticulocyte to become mature Erythrocyte
(Kung wala ni dili ma remove ang RNA mahimong Basophilic stippling)

A

Pyrimidine-5-nucleotidase

Hematology (9 decks)

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