Anemia

Question 1

Not a disease defined as the decrease below normal or one or more

Answer 1

Anemia

Question 2

rare but potentially deadly bone marrow failure syndrome

Answer 2

Aplastic anemia

Question 3

most frequently implicated drug in aplastic anemia

Answer 3

Chloramphenicol

Question 4

asso. w/ identified cause, some of the causes include chemicals and viruses/ drugs

Answer 4

Secondary Acquired Aplastic Anemia

Question 5

most common of the inherited aplastic anemia

Answer 5

Fanconi Anemia

Question 6

What are the physicl abnormalities include in Fanconi Anemia

Answer 6

Skeletal Abnormalities
Skin pigmentation
Short stature
Abn. eyes, kidney and genitals

Question 7

Hyperpigmentation, Hypopigmentation, cAFE-AU-LAIT LESIONS

Answer 7

Physical abnormalities in Fanconi anemia asso. w. skin pigmentation

Question 8

Thumb malformation, Microcephaly, Scoliosis

Answer 8

Physical abnormalities in Fanconi anemia: Skeletal abn.

Question 9

PNH is also known as

Answer 9

Marchifava-Micheli Syndrome

Question 10

It is caused by deficiency of DAF (CD 55) and MIRL (CD 59)

Answer 10

PNH

Question 11

Confirmatory test for PNH

Answer 11

Flow cytometry

Question 12

Tests for PNH

Answer 12

Ham’s Acidified Serum Test
Sugar water Test
Flow Cytometry

Question 13

examples of complementary regulatory proteins

Answer 13

DAF
Membrane Inhibitor of Reactive Lysis (MIRL)

Question 14

Most common anemia among hospitalized patients, Ass. w/ chronic infxn, body store have abundant Iron

Answer 14

Anemia of Chronic Inflammation

Question 15

Central feature of ACI

Answer 15

Sideropenia (Decreased serum iron)

Question 16

Acute phase reactants that contribute to ACI

Answer 16

Hepcidin
Ferritin
Lactoferrin

Question 17

Master regulatory hormone for systemic iron metabollism inactivates FERROPORTIN

Answer 17

Hepcidin

Question 18

Transport iron from Tissue to the Blood

Answer 18

Ferroportin

Question 19

develop when the production of Protoporphyrin or the incorporation of iron into Protoporphyrin is Prevented; iron is trapped in the Mitochondria

Answer 19

Sideroblastic Anemia

Question 20

NCULEATED RBC precursor w/ Cytoplasmic Iron Granules

Answer 20

Sideroblast

Question 21

ANucleate RBC w/ Iron granules

Answer 21

Siderocyte

Question 22

ANucleate RBC w/ Iron granules

Answer 22

Siderocyte

Question 23

Hallmark of the Sideroblastic Anemia

Answer 23

Ring Sideroblasts

Question 24

Most common anemia, caused by Blood loss/ Nutitional def/ ^ iron demands/ Malignancies of GI tract/ Hookworm Infxn

Answer 24

IDA

Question 25

spooning of the fingernails

Answer 25

Koilonychia

Question 26

cravings for non-food items

Answer 26

Pica

Question 27

craving for ICE

Answer 27

Pagophagia

Question 28

indirectly measures the conc. of transferrin by measuring its ability to bind iron

Answer 28

TIBC

Question 29

the first laboratory test to become abnormalwhen iron stores begin to decline; revelas the body's tissue iron stores

Answer 29

Serum Ferritin

Question 30

caused by the lack of intrinsic factor

Answer 30

V B12 deficiency

Question 31

Found in the stomach produce HCI and IF

Answer 31

Parietal cells

Question 32

a type of megaloblastic anemia caused by inadequate intake, Increased need, renal dialysis

Answer 32

Folate deficiency

Question 33

Considered as the root cause of megaloblastic anemia

Answer 33

Impaired DNA synthesis

Question 34

DNA synthesis is dependent on an important structure called

Answer 34

Thymidine Triphosphate (TTP)

Question 35

VB12 is also known as

Answer 35

Cobalamin

Question 36

Synthetic form of VB12 found only in supplements

Answer 36

Cyanocobalamin

Question 37

naturally occuring form that may be obtained from either food sources or supplements

Answer 37

Methylcobalamin

Question 38

loss of epithelium on the tongue results in a smooth surface and soreness

Answer 38

Glossitis

Question 39

Laboratory test that differentiate Folate def. and VB12 Def.

Answer 39

holoTC assay

Question 40

Other possible findings in megaloblastic anemia ''TNBCH''

Answer 40

Teardrop cells Nucleated RBCs Howell-Jolly bodies Basophilic Stippling Cabot rings

Question 41

Metabolically active form of VB12

Answer 41

Holotrancobalamin

Question 42

Disorders characterized by impaired synthesis of HEME, example: LEAD POISONING

Answer 42

Porphyrias

Question 43

LEAD can inhibit enzymes in the body including

Answer 43

Ferrocheletase adn Pyrimidine-5-Nucleotidase

Question 44

enzyme needed to completely remove the RNA remnants from reticulocyte to become mature Erythrocyte (Kung wala ni dili ma remove ang RNA mahimong Basophilic stippling)

Answer 44

Pyrimidine-5-nucleotidase