WBC Flashcards
Two type of phagocytes
Mononuclear and granulocytes
Types of phagocytes which arise from the bone marrow and are released as monocytes.
Mononuclear
How long will it take monocytes to differentiate into becoming macrophages?
Hours to days
3 classifications of granulocytes
Neutro, eosino, and baso
5 stages of phagocytosis. (In order)
-Chemotaxis
-Attachment to organism
-Ingestion
-Fusion of cell lysosomes with ingested microorganism and bacterial killing
-Digestion
Movement of an organism in response to a chemical stimulus
Chemotaxis
Where should ingested pathogens bind order to be digested by paghocytes?
Lysosomes
WBC responsible for the defense against metazoan parasites and modulating inflammatory processes.
Eosinophils.
T or F
Eosinophils respond chemotactically to histamine.
T
T or F
Basophils are true phagocytes.
F
Granulocyte which contains large amounts of histamine and other mediators of inflammation.
Basophils
What controls the production and circulation of WBCsand RBCs?
Colony stimulating factors and interleukins
Functions of lymphocytes in terms of different immunity.
Humoral and cellular immunity
Where are t-cells produced?
Bone marrow. Once these lynphocytes are produced, they then migrate to thymus and differentiate into different thymic hormones.
Where are t-cells mostly located?
Thymus. (Tho some/few are located in the spleen and lymph node.)
Differentiate t-lymphocytes and b-lymphocytes in terms of their immunologic responsibilities and location in the lymph node
T- cytotoxic immunity (parafollicular zones)
B - humoral immunity (follicular zones)
Lymphocytes are either efferent and afferent.
T
How do B-cells react to an antigen?
Thru cloning (division) into plasma cells that produce antibodies.
Immunoglobulin which responds first to respiratory and intestinal secretions.
IgA
Immunoglobulin which responds first to newly recognized antigen.
IgM
Immunoglobulin which responds first to an antigen in the blood.
IgG
Immunoglobulin which responds first to allergy
IgE
Type of lymphocyte which eliminates foreign cells even without sensitization.
Natural killer cells
How do basophils and mast cells induce systemic anaphylaxis?
When exposed to an allergen, IgE are bound on the surface of basophils and mast cells causing degranulation. This results to the release of vasoactive amines (PAF 30k more potent than histamine)
Antibody which is a part of the b-cells that activates basophils and mass cells.
IgD (IgE ata to ah)
Type of immunity which produces antigen specific antibodies in response to an antigen.
Humoral immunity
Type of immunity primarily driven by T-cells
Cell-mediated immunity
What cells are responsible for cell-mediated immunity?
T-cells, macrophages, and cytokines
