PLATELETS Flashcards
Blood responsible for the source of phospolipid
Platelets
What is responsible for the production of platelets in the bone marrow?
Megakaryocytes, under the influence of thrombopoeitin.
How is platelet produced?
A megakaryocyte is first invaginated and a cytoplasmic island is formed. When the cytoplasmic islands are fragmented, a platelet is formed.
T or F
Platelets are granulated.
T
ADP or ATP
What is responsible in aiding the platelets’ change of shape in response to their adherence to a damaged tissue?
ADP
Define von Willebrand factor
The adherence of circulating platelets to a damaged tissue. Particularly the endothelium
Define hemostatic plug
Local accumulation of fibrin and platelets
Platelet count before the risk of hemorrhagic distress.
<30 000/microliter
Decrease in three hematologic cell line
Pancytopenia
T or F
Most thrombocytosis and thrombocytopenia are rare and often idiopathic.
F - thrombocytosis is rare, but thrombocytopenia is undocumented to be idiopathic.
T or F
Myeloproliferative diseases can cause sequestration of platelets.
T
Name one drug which causes platelet aggregation.
Aspirin
(charot, corticosteroid dapat, prednisone, prednisolone, and dexamethasone. Aspirin causes platelet decumulation)
What happens when thromboxane’s mechanism of action is inhibited by a drug?
Hemostatic plug and platelet aggregation is compromised.
