Ways to improve treatment response

Question 1

What issues have there been surrounding prevention of affective disorders?

Answer 1

Traditionally they have not been effective

Costly and unethical to treat those without illness

Therefore, non-pharmologoical prevention is used mainly:

Question 2

What prevention interventions have been used?

Answer 2

IPSRT/Psychoeduction for prevention of episodes

Online treatment for suicide preventions

Prodrome or relapse: Machine learning or passive data

Family therapy

Question 3

How can early intervention improve treatment response?

Answer 3

1: Currently long delay in treatment
2: Longer the delay in treatment the longer the worse the outcome
3: Early intervention in psychosis proven to be beneificial- for individual and cost

Question 4

What are some of the issues facing early intervention research?

Answer 4

Diagnosis are currently delayed
Long term study is required, costly
Lack of evidence reduces investment

Question 5

Why is Personalisation an important factor in treatment of affective disorders?

Answer 5

Inflammation has been shown to decrease response to antidepressants

HPA axis and cortisol levels have been shown to decrease the response to therapies.

But there is evidence that each also reduce reaction to treatment generally.

Question 6

What non-biological factors have been seen to effect treatment?

Answer 6

Prior Illness severity: Number of previously unsuccessful treatments predict worse outcomes.

Question 7

What has the research on the whole shown regarding Personalisation of treatment?

Answer 7

It has all been fairly inconsistent therefore work has been done on multi-modal predictors