Research of mechanism

Question 1

In what ways has heterogeneity in Depression been an issue?

Answer 1

Fried (2017)

Over 1000 unique symptom combinations

Co-morbidity, course, treatment differs

treated as unitary disease

Severity score is too simplistic

Question 2

How is research in affective disorders attempting to improve?

Answer 2

By making homogenous groups:

Collaborative: 
Using Rdoc:
-Domain
-Mechanism
-Splitting diagnosis 

Theory informed:
Data Driven:
Combination

Network:

Multimodal

Question 3

How does computational modelling work?

Answer 3

Past: Individual hypothesis testing-nuances lost

Computational replica of cognitive mechanisms- allows computational models

Question 4

What study showed the potential in computational models?

Answer 4

Camacho:

Treatment reaction of individuals.

Not universally accepted

Question 5

What is the future of computational modelling?

Answer 5

Mapping of mechanism

Specific examination

Study of which models are transdiagnostic

Question 6

What is the brief history of Biological marker research in mood disorders?

Answer 6

Monoamine theories
Brain scans then suggested structure and networks
Neuroendocrine: Cortisol and HPA axis
Neurogenesis 
Inflammation
Genetic: candidate then GWAS