Warfarin

Question 1

what is warfarin

Answer 1

A Vitamin K antagonist

Question 2

when is Warfarin used

Answer 2

in the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF)

Question 3

how can warfarin cause foetal bleeding, spontanuos abortion and neonatal death?

Answer 3

because it can cross the placental barrier during pregnancy

Question 4

what does warfarin inhibit

Answer 4

vit k reductase

Question 5

what was does warfarin reduce the levels of?

Answer 5

reduced form of vitamin k As vitamin K is required for the production of coagulation factors II, VII, IX, and X and anticoagulant proteins C and S, these levels also drop.

Question 6

what is vitamin k required for?

Answer 6

the production of coagulation factors II, VII, IX, and X and anticoagulant proteins C and S

Question 7

what does Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in

Answer 7

decreased prothrombin levels, decreased thrombin generation and reduced ability to form a clot.