Prednisolone

Question 1

what is prednisolone

Answer 1

A glucocorticoid receptor agonist

Question 2

what is prednisone derived from?

Answer 2

cortisone

Question 3

describe the metabolism of prednisolone?

Answer 3

metabolised in the liver to its active form, prednisolone

Question 4

what happens when the prednisolone is metabolism

Answer 4

Prednisolone can cross the cell membrane and can bind to the cortisone receptor

Question 5

what happens when the cortisone receptor is bound to?

Answer 5

This leads to changes in DNA transcription reducing the production of inflammatory proteins.

Question 6

give an example of what happens cortisone receptor is bound to?

Answer 6

One specific example is the reduction in the activity of phospholipase A2, leading to the reduced production of arachidonic acid. It can also affect the cell membrane altering ion permeability, and also can affect neurohormone production