Cyclosporin Flashcards
1
Q
what is cyclosporin
A
An immunosupressive agent (A cyclophilin binder)
2
Q
what is cyclosporin used for
A
Cyclosporin is used as an immunosuppressive agent, used for the prophylaxis of graft rejection in organ and tissue transplantation.
3
Q
how does cyclosporin work?
A
. It binds to cyclophilin, which causes the inhibition of calcineurin, which is responsible for activating the transcription of IL-2. This causes a reversible inhibition of immunocompetent lymphocytes, in the G0 or G1 phase of the cell cycle. T-lymphocytes are preferentially inhibited, with the T1-helper lymphocyte is the main target, although it may also inhibit the T1-suppressor cell.
