Clopidogrel

Question 1

what is clopidogrel

Answer 1

A P2Y12 antagonist.Clopidogrel is an anti platelet therapy agent. It is a prodrug

Question 2

what does clopidogrel need to produce the active metabolite

Answer 2

requires metabolism by CYP450

Question 3

mode of action of Clopidogrel

Answer 3

Its mode of actin is the irreversible blocking of the P2Y12 receptor, and thereby blocking the binding site of ADP

Question 4

what is ADP

Answer 4

ADP is both a direct platelet agonist, and is also secreted by the platelet

Question 5

what does ADP act as

Answer 5

a secondary agonist that is critical to complete platelet activation

Question 6

what happens after the activation of the GPIIb/IIIa receptor is reduced

Answer 6

to a reduction in fibrinogen binding and thrombus formation

Question 7

what does Clopidogrel do for patients with an elevated risk of arterial thrombus

Answer 7

clopidigrel acts to reduce the risk of a significant thrombotic effect