Lepirudin Flashcards
1
Q
what is lepirudin
A
An anti-thrombin agent which is a a highly potent and selective agent
2
Q
what is lepirudin a recombinant form of?
A
hirudin
3
Q
what happens when lepirudin forms a stable non-covalent complex with alpha thrombin
A
prevents fibrinogen cleavage and initiation of the clotting cascade.
4
Q
lepirudin was withdrawn 4 years ago. what has it been replaced with
A
Dabigatran (direct thrombin inhibitor) or Apixaban (A factor Xa inhibitor)
