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Biochem Block 4, 5 > Warfarin > Flashcards

Warfarin Flashcards

1
Q

What is an important substrate of CYP2C19?

A

Warfarin,…

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2
Q

Substrates of CYP2C9?

A

Ibuprofen, Plavix (Clopidogrel, anti platelete aggregation), Phenytoin

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3
Q

Location of CYP2C9

A

10q23.3

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4
Q

What is Warfarin?

A

Anti-clotting agent:
Warfarin activates VKOR -> VKOR converts Vitamin K in its reduced form and thereby reduces clotting

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5
Q

How does CYP2C9 metabolize Warfarin

A

CYP2C9 removes S-Warfarin

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6
Q

What is the effect of high/low amounts of CYP2C9 activity?

A

LOW activity: less removal of Warfarin, excess warfarin -> bleeding

HIGH activity: too much removal of Warfarin, increased clotting -> risk of stroke

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7
Q

Why is it important to monitor the level of Warfarin?

A

Because it has 40 hr of half-life

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8
Q

Optimal dose range for Warfarin?

A

2 mg/day to 10 mg/day

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9
Q

The first step of finding individual dose?

A

Measuring INR

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Biochem Block 4, 5 (20 decks)

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