SARS CoV

Question 1

Where in the body can we find ACE2?

Answer 1

Nose, heart, gut, and lungs

Question 2

Function of ACE2

Answer 2

Its activities and cellular interactions control wound repair, inflammation, and blood pressure

Question 3

Where does SARS-CoV spike protein bind with high affinity?

Answer 3

ACE2 10-20x higher

Question 4

The function of Angiotensin 1+2 and ACE 1+2

Answer 4

Angiotensin 1 gets converted to Angiotension 2 by ACE-1 -> too much ACE-1 causes too much conversion of Angiotensin 1 ->edema, tissue damage, inflammation

Angiotensin 2 binds to ACE-2 and gets removed -> too much Angiotensin 2 cause damage
ACE-2 promotes validation, and protection and stops fibrosis (thickening of tissue)

Question 5

What is the effect of SARS-CoV on ACE2

Answer 5

Too much Angiotensin 2 causes damage to blood vessels and tissue injuries -> so Angiotensin 2 (converted from Angiotensin 1 by ACE-1) gets removed by ACE-2

SARS-CoV blocks ACE-2 -> so ACE-2 cant remove Angiotensin 2 anymore -> Angiotensin 2 builds up and causes damage