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Biochem Block 4, 5 > Codeine > Flashcards

Codeine Flashcards

1
Q

The function of CYP2D6 (Debrosin Hydroxylase):

A

catalyzes the hydroxylation (-OH) of its substrates -> activates Debrosin (lowers blood pressure)

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2
Q

How many known CYP450 genes are in humans?

A

58 genes in 18 families, and 43 subfamilies

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3
Q

What are the outcomes for PM and UM:

A

PM: no analgesia
UM: risk of toxicity

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4
Q

Therapy recommendations for specific codeine metabolizers?

A

NM an IM: Label recommended weight and age dosing
UM an PM: avoid codeine, look for alternatives

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5
Q

Common substrates of CYP2D6?

A

Tramadol, Codeine, Oxycodone, Fluoxetine, SSRI (antidepressiva)

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6
Q

Common substrates for CYP2C?

A

Ibuprofen, Phenytoin, Plavix, Warfarin

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Biochem Block 4, 5 (20 decks)

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