DNA Replication Flashcards
1
Q
How are the single units of the DNA chain connected?
A
Bonds are made between sugars and phosphates
2
Q
The phase of separation of 2 chromosomes:
The Phase of replication (synthesis):
A
Separation: Mitosis
Replication: S-Phase
3
Q
How many base pairs per helix turn?
A
10 bp creating major and minor groove
4
Q
Number of H-bonds A to T, C to G
A
A - T: 2 H bonds
c- G: 3 H bonds
1 bond between N and N, 1 between C=O and amino group
5
Q
What is the meaning of a semi-conservative replication?
A
1 old and 1 new strand
6
Q
Causes of DNA variations?
A
Replication, spontaneous changes in bases, environmental damages
One or more base pairs: Deletion and Insertion
Moving 1000s of bp and rearranging them: Translocation
7
Q
Frequency of SNP´s and mutations?
A
SNP: > 1%
mutations: <1%
