W8/L7 Flashcards
1
Q
What 3 things contribute to the airway obstruction in asthma?
A
Vasoconstriction
Bronchial wall oedema
Mucus production
2
Q
What physiological mediators promote relaxation of the airway smooth muscle?
A
Adrenaline
PGE2
3
Q
What physiological mediators promote constriction of the airway smooth mucle?
A
Histamine
Leukotrienes
ACh
4
Q
How is the histological appearance of an asthmatic’s airways different?
A
- Goblet cell metaplasia
- Subepithelial collagen thickening
- Infiltration of inflammatory cells
- Increased mucosal vascularity
Increased SM volume.
5
Q
What are some SABAs?
A
Salbutamol
Terbutaline
6
Q
What are some A/E of SABAs?
A
Tachycardia
Tremor
Hypokalaemia
7
Q
How fast is the onset of action of SABAs?
A
2-5 minutes
