W8/L10: Viral pathogenesis

Question 1

Which are the type 1 interferons?

Answer 1

IFN-alpha

IFN-beta

Question 2

Which is the type 2 interferon?

Answer 2

IFN-gamma

Question 3

What are the actions of type 1 interferons?

Answer 3

1. Inhibits viral replication
2. Activates NK cells
3. Enhanced MHC I expression

Question 4

Which cells produce type 1 interferon?

Answer 4

Virus-infected macrophages, DCs and tissue cells

Question 5

What are the actions of type 2 interferon?

Answer 5

1. Inhibits viral replication
2. Activated macrophages
3. Enhances MHC I and II expression

Question 6

Which cells produce type 1 interferon?

Answer 6

NK cells

and T cells

Question 7

How does HIV interfere with the presentation of viral antigens to CD8 T cells?

Answer 7

HIV Nef induces the endocytosis of class I MHC

Question 8

How does HSV interfere with the presentation of viral antigens to CD8 T cells?

Answer 8

HSV protein binds to the cytosolic side of TAP, and prevents transfer of peptides to the ER

Question 9

How does CMV interfere with the presentation of viral antigens to CD8 T cells?

Answer 9

CMV protein binds to TAP on the luminal side, and prevents peptide translocation to the ER