W8/L6: Allergies Flashcards
1
Q
What’s the name for the high-affinity IgE receptor?
A
FcϵRI
2
Q
What part of the FcϵRI do IgE antibodies bind to?
A
The alpha subunits
3
Q
Mast cell activation: the immediately released mediators are ___
A
Histamine
Heparin
Tryptase
(TNF-alpha)
4
Q
Mast cell activation: the rapidly mediators are____
A
Cys-LTs
PGD2
5
Q
Mast cell activation: the slowly released mediators are _____
A
IL-4
IL-5
GM-CSF
6
Q
What does Histamine action on H1 receptors cause?
A
Pain & itch Bronchospasm Mucus secretion Vasodilation (-> hypotension) Increased vascular leak (-> hypovolaemia) Wakefullness in CNS
7
Q
What are chronotropic effects?
A
Ones that change HR
8
Q
What are inotropic effects?
A
Ones that change the force of muscle contraction (often in reference to heart)
9
Q
What foes histamine action on H2 receptors cause?
A
Gastric acid secretion
Positive inotropic & chronotropic effects
10
Q
AA metabolism: which enzymes liberate cell membrane phospholipids?
A
PLA2
PLC
