W6 - Lymphoreticular System

Question 1

Where do the T-cells go to mature?

Answer 1

Thymus

Question 2

What increases in the thymus as you age?

Answer 2

Adipose tissue

Question 3

What part of the thymus has majority T-cells?

Answer 3

Paracortex

Question 4

What part of the thymus has majority B-cells?

Answer 4

B cells

Question 5

What cells are found in the medullary cords of the lymph nodes?

Answer 5

Plasma cells

Question 6

The germinal centres of the lymph node are equivalent to the ???? in the spleen?

Answer 6

White pulp

Question 7

T-cells come from the bone marrow go to the thymus to mature, where on the thymus do they enter?

Answer 7

Corticomedullary junction

Question 8

What is an MHC?

Answer 8

Major Histocompatibility Complex

Question 9

What type of cells promote T-cell maturation?

Answer 9

Thymic nurse cells

Question 10

What is the purpose of the medulla?

Answer 10

To remove T-cells that recognise the normal body as non-self

Question 11

In the cortex/medulla of the thymus, is there +ve or -ve selection of T-cells?

Answer 11

Cortex +ve, medullary -ve

Question 12

What do CD4 and CD8 cells do?

Answer 12

Helper and cytotoxic

Question 13

What is the pink swirly material in a Hassall’s corpuscle?

Answer 13

KEratinised epithelial cells

Question 14

How to differentiate between primary and secondary follicles in lymph nodes?

Answer 14

Primary - purple throughout, Secondary - have a light purple patch within

Question 15

What cells are found in germinal centre of the secondary follicles?

Answer 15

Activated B-cells

Question 16

What region of the lymph nodes are follicles found in?

Answer 16

Cortex

Question 17

Where is the paracortex and what cells are found there?

Answer 17

Between/around follicles, T-cells

Question 18

Germinal centres are present in the white pulp of the spleen too, what cells are found there?

Answer 18

B-cells

Question 19

What does PALS stand for?

Answer 19

Periarteriolar Lymphoid Sheaths

Question 20

What cells are found in the PALS?

Answer 20

T-cells

Question 21

Dendritic cells have long cytoplasmic processes, why?

Answer 21

Increase surface area to present more antigens and closely associate to lymphocytes

Question 22

MHC class 1 are found on all cells apart from…

Answer 22

RBCs

Question 23

MHC class 1 antigens are presented to…

Answer 23

CD8 (cytotoxic T-cells)

Question 24

MHC class 2 are found on ….

Answer 24

APCs only

Question 25

What is the main function of the lymph nodes?

Answer 25

Generates and effective, adaptive immune response

Question 26

THe LN have zones of B+T cells