W4: Pharmacodynamic mechanism of drug-drug interaction

Question 1

How can we alter drug action without changing its serum concentration?

Answer 1

By changing the drug’s interaction at single/various/unspecific receptor sites. This is the goal of pharmacodynamics interaction.

Question 2

How will pharmacokinetics be affected in pharmacodynamic interaction?

Answer 2

Pharmacokinetics should NOT be affected and should not affect pharmacodynamic interaction.

Question 3

Receptor site interaction include _________ the cellular targets.

Answer 3

competitively inhibiting

Question 4

Explain synergism.

Answer 4

The combination of two drugs is greater than summation of action from two drugs.

1+1 > 2

Question 5

Explain summation.

Answer 5

The total responses from the two co-administered drugs.

1+1 = 2

Question 6

What is one consequence of synergism?

Answer 6

Causing an unexpected increase in pharmacological activity = potentiation (beneficial effects)

Question 7

Loss of ________ and increase in _______ is a consequence of drug interaction.

Answer 7

loss of therapeutic effects and increase in toxicity = antagonism (unintended effects)

Question 8

What is IV incompatibility about?

Answer 8

It is about when different drugs that are incompatible mixes in the IV fluid, the risk of complication is high.