W2: Route of administration

Question 1

Enteral route means the absorption of drug through the __________.

Answer 1

small intestine

Question 2

Enteral route of administration includes oral, _________ and ________.

Answer 2

Oral, sublingual and rectal

Question 3

Parenteral route of administration includes intravenous,________,__________ and _______.

Answer 3

Intravenous, intramuscular, intradermal and subcutaneous

Question 4

Topical route is low in _______________.

Answer 4

low in lipid and water content.

** This is a barrier to drug absorption

Question 5

Topical route of administration includes intranasal, __________ and _________.

Answer 5

Intranasal, inhalation and intravaginal

Question 6

What are the disadvantage of oral administration?

Answer 6

• Inefficient absorption due to first pass effect
• Irritation to gastric mucosa
• Certain drugs are destroyed by gastric acid
• cannot be used in unconscious patients

Question 7

In first pass effect, drugs given orally will be transported to_________ via_________. This is known as portal circulation or __________.

Answer 7

transport to liver via portal vein. This is known as portal circulation or hepatic circulation.

Question 8

There will be more drugs bioavailable after first pass effect. True or False?

Answer 8

False. The bioavailability will decrease because liver destroys some of the drug administered. Lesser drug enter the systemic circulation.

Question 9

Subcutaneous injection is at the _____ layer.

Answer 9

dermis

Question 10

Intradermal injection is at the __________ layer.

Answer 10

epidermis

Question 11

_________ and ________ administration is affected by tissue composition.

Answer 11

Intramuscular and subcutaneous

Question 12

Drugs that are given intravenously usually has a shorter __________.

Answer 12

Shorter half life

Question 13

Arrange the route of administration based on these criteria:
Oral, IV, IM, SC

1. Safety
2. Convenience
3. Cost
4. Bioavailability
5. Onset of action
6. Patient compliance

Answer 13

1. Safety = Oral > SC > IM > IV
2. Convenience = Oral > SC > IM > IV
3. Cost = IV > IM > SC > Oral
4. Bioavailability = IV > IM = SC > Oral
5. Onset of action = IV > IM > SC > Oral
6. Patient compliance = Oral > SC > IM > IV

Question 14

Name a few types of drug formulation

Answer 14

Tablets, Aerosol, capsule, suspension, cream infusion etc.