W32/L4

Question 1

Which lab technique used the CIN grading system?

Answer 1

Cervical histology

Question 2

Which lab technique uses the low grade/high grade lesion grading system?

Answer 2

Cervical cytology

Question 3

What’s the genetic material of HPV

Answer 3

dsDNA

Question 4

In which regions (of the world) is cervical cancer especially common?

Answer 4

Developing countries

Question 5

What HPV strain accounts for 70% of cervical cancers?

Answer 5

16

Question 6

What HPV strain accounts for 20% of cervical cancers?

Answer 6

18

Question 7

Which HPV gene transcript inhibits the transcription of E6 and E7

Answer 7

E2

Question 8

Which HPV protein deactivates p53?

Answer 8

E6

Question 9

Which HPV protein deactivates Rb

Answer 9

E7

Question 10

The genes of HPV are split into two groups, what are they?

Answer 10

Early and late

Question 11

What process causes increased transcription of E6 and E7?

Answer 11

Chromosomal integration of the genome, which disrupts E2

Question 12

What part of the cervix is most susceptible to HPV infection?

Answer 12

The cervical transformation zone