W31/L2: Congenital infections

Question 1

What is the syndrome cause by fetal infection with VZV?

Answer 1

Congenital varicella syndrome

Question 2

What are some common outcomes of VZV infection in the 1st trimester?

Answer 2

Limb hypoplasia
Cicatricial scarring
Microcephaly
Mental retardation

Question 3

When is the most dangerous time for a mother to contract VZV?

Answer 3

Perinatally (-7 to +2 dyas from deliver)

Question 4

What is the mortality rate to babies for perinatal VZV infection?

Answer 4

30%

Question 5

Why do we give prophylactic VZIG to premature babies?

Answer 5

Most Abs cross the placenta in the 3rd trimester, so even if mum had immunity, they won’t be protected

Question 6

What’s the viral phenotype of cytomegalovirus?

Answer 6

Lipid envelope
Icosahedral capsid
dsDNA

Question 7

Of primary congenital infections with CMV, what percent of babies are born symptomatic?

Answer 7

10%

Question 8

Of the babies born symptomatic for primary congenital CMV, what percentage have long term sequelae?

Answer 8

90%

Question 9

What’s the common adult presentation with rubella?

Answer 9

Low grade fever
Lymphadenopathy
Maculopapular rash
Polyarthralgia / arthritis of the large joints

Question 10

Which nodes tend to be enlarged in rubella?

Answer 10

Occipital
Post auricular
Posterior cervical

Question 11

What’t the classic triad of congenital rubella syndrome?

Answer 11

Abnormalities in:
Opthalmological
Cardiac
Auditory

Question 12

What’s the virus also known as arythrovirus?

Answer 12

Parvovirus B19