W30 Adverse effects of drugs on the liver

Question 1

What drugs are hepatotoxic

Answer 1

Type A (‘Augmented’)
- Bilirubin metabolism and excretion:
- Steroids, androgens, oestrogen,contraceptives,
Rifampicin
Centrilobular necrosis:
-Paracetamol, carbon tetrachloride
Hepatocellular necrosis:
- Salicylates
Fatty change and liver failure:
- Tetracycline

Type B (‘Bizarre’):
Acute hepatocellular necrosis
Methyldopa
Antidepressants (MAOI)
Ibuprofen
Antiepileptics
Choleostatic hepatitis
Chloromazine
Type C (`Chronic treatment effects’)
Benign liver tumour
Anabolic steroids
Contraceptives
Chronic active hepatitis
Isoniazid
Dantrolene
Hepatic fibrosis / cirrhosis
Methotrexate
Amiodarone