W29/L3 Flashcards
1
Q
Which molecule is the negative regulator of muscle mass?
A
Myostatin
2
Q
Define sarcopenia
A
Age-associated loss of skeletal muscle mass & function
3
Q
What’s the word for inflammatory-related muscle loss?
A
Cachexia
4
Q
What is meant by muscle weakness?
A
An inability to develop and initial force appropriate for the circumstances
5
Q
Which group of muscles appear to be affected by age earlier?
A
The fast muscles
6
Q
What’s a motor unit?
A
A particular neuron and the muscle fibres it controls
7
Q
What two changes do we see in the muscle fibres with age?
A
Atrophy due to denervation of some type II motor units.
Re-enervation with type I - so more slow fibres
8
Q
What changes happen to the motor end plate in sarcopenia?
A
Loss of side plates
Longer nerve terminals
Widened end-plate
