W27/L9

Question 1

What are some examples of sulfonylureas

Answer 1

Chlorpropramide
Glibenclamide
Glipizide

Question 2

What’s the MoA of sulfonylureas?

Answer 2

Inhibit K-ATP channels in beta cells

Cause depolarisation of the cell

Exocytosis of insulin

Question 3

What are some A/E of sulfonylureas?

Answer 3

Hypoglycaemia

Weight gain

Question 4

What’s an example of a biguanide?

Answer 4

Metformin

Question 5

What’s the MoA of metformin?

Answer 5

Activates AMP kinase to supress gluconeogenesis, and increase GLUT4 glucose uptake

Question 6

What’s an alpha-glucosidase inhibitor?

Answer 6

Acarbose

Question 7

What’s the MoA of acarbose?

Answer 7

Blocks the enzymes that digest starches in the small intetine

Question 8

A/E of acarbose?

Answer 8

Flatulence, bloating, loose stools, abdo pain

Question 9

What’s an example of the DPP-4 inhibitors?

Answer 9

Sitagliptin

Question 10

What’s the MoA of sitagliptin?

Answer 10

Increases GLP levels

Question 11

List 5 pharmeceutic strategies for managing T2DM

Answer 11

1. Stimulate insulin secretion
2. Sensitise body to insulin
3. Slow CHO absorption
4. Mimic incretin activity
5. Block renal glucose absorption

Question 12

Which drugs are used to stimulate insulin secretion?

Answer 12

Sulfonylureas

Question 13

Which drugs are used to sensitise the cells to insulin?

Answer 13

Biguanides

Question 14

Which drugs are used to slow CHO absorption?

Answer 14

a-glucosidase inhibitors

Question 15

Which drugs are used to mimic incretins? (2)

Answer 15

DPP-4 inhibitors

GLD agonists

Question 16

Which drugs are used to block renal glucose reabsorption

Answer 16

Na-Glucose cotransporter 2 inhibitors