W27/L1

Question 1

Many undiagnosed diabetics think they’re peeing a lot cause they’re drinking a lot. Is this correct?

Answer 1

No the polyuria is causing the polydipsia via dehydration

Question 2

How long after T1DM diagnosis is C protein still detectable in the blood?

Answer 2

5-10 years

Question 3

What are the unmodified long-acting human insulins?

Answer 3

Humulin NPH

Protaphane

Question 4

What is the most used insulin in the world?

Answer 4

Glargine

Question 5

How long is glargine active for?

Answer 5

24 hours

Question 6

What modifications does Detemir have?

Answer 6

Deletion of B30 and a fatty acid added

Question 7

What are the effects of the modifications on Detemir?

Answer 7

The fatty acid binds to albumin which protects the insulin from degredation

The fatty acis allows Detemir to cross the BBB, which means it can interact with hunger centres & inhibit appetite

Question 8

What makes the short-acting insulins short acting?

Answer 8

The speed at which they’re absorbed from the subcutaneous tissue

Question 9

What is “basal bolus” dosing?

Answer 9

Refers to using one long-acting insulin (the basal dose), and an injection of short-acting immediately before each meal

Question 10

Why use basal bolus dosing?

Answer 10

It mimic physiological insulin secretion

Question 11

How is dosage different with insuling pumps?

Answer 11

Short-acting insulin is delivered continuously, and the user pushes a button to get a bolus dose each meal

(There is no need for long-acting insulin)

Question 12

Are insulin pumps “open loop” or “closed loop”, and why?

Answer 12

They’re open loop, as the user is the one determining their dose

Question 13

Are artificial pancreases “open loop” or “closed loop” and why?

Answer 13

They’re closed loop, as the device is determining the necessary insulin flow.