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Metabolism > W27/L2 > Flashcards

W27/L2 Flashcards

1
Q

The vast majority of the pancreas has what function?

A

Exocrine

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2
Q

What percentage of the pancreas has endocrine activity?

A

2%

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3
Q

What 4 cells are found in the Islets of Langerhans?

A

Alpha
Beta
Delta
Theta

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4
Q

Beta cells make up what proportion of cells in the Islet?

A

80%

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5
Q

Alpha cells make up what proportion of cells in the Islet?

A

10%

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6
Q

Delta cells make up what proportion of cells in the Islet?

A

5%

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7
Q

Theta cells make up what proportion of cells in the Islet?

A

5%

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8
Q

What do beta cells produce?

A

Inuslin

Amylin

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9
Q

What do alpha cells produce?

A

Glucagon

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10
Q

What do delta cells produce?

A

Somatostatin

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11
Q

What do theta cells produce?

A

Pancreatic polypeptide

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12
Q

Where in the Islet are the beta cells found?

A

In the centre

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13
Q

Where in the Islet are the alpha, delta, and theta cells found?

A

Around the mantle

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14
Q

What are the components of preproinsulin?

A

Signal protein, A, B and C petides

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15
Q

What are the components of proinsulin?

A

A, B and C peptides

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16
Q

What converts preproinsulin to proinsulin and how?

A

Prohormone convertase 2 cleaves the signal protein

17
Q

What are the components of insulin?

A

A and B peptides

18
Q

What converts proinsulin to insulin and how?

A

Prohormone convertase 1 cleaves the C protein

19
Q

Insulin secretion occurs in 2 phases - what are they?

A

1st phase - lasts 2-5 minutes and is a sharp rise in secretion

2nd phase - lasts the duration of the stimulus and is a prolonged secretion

20
Q

What is thought to explain the sharp rise in insulin levels in phase 1?

A

Release of insulin from vesicles already near the cell surface.

21
Q

What are some of the exocrine products of the pancreas?

A 
Bicarbonate
Amylse
Trypsin
Chymotrypsin
Carboxypeptidase

Metabolism (7 decks)

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