Vulva

Question 1

Bartholin cysts are located

Answer 1

lower vestibule adjacent to vaginal canal

Question 2

HPV subtypes
low risk
high risk

Answer 2

low risk: HPV 6 or 11

high risk: 16, 18, 31, 33

Question 3

Condyloma etiology

Answer 3

HPV 6 or 11

Question 4

HPV-infected cells histology

Answer 4

koilocytes–coiled nuclei

“raisinoid” nuclei

Question 5

Lichen sclerosis

Answer 5

thin epidermis with hypertrophy of dermis
occurs in leukoplakia area
slightly increased risk for squamous cell carcinoma

Question 6

Lichen simplex chronicus

Answer 6

hyperplastic epidermis
2˚ to chronic irritation and scratching
leukoplakia with thicker, leathery skin
no increased risk for squamous cell caricnoma

Question 7

Lichen sclerosis vs lichen simplex chonicus

Answer 7

scerlosis: thinning of epidermis, increased risk for squamous cell carcinoma
simplex chronicus: thickening of epidermis, increased risk for squamous cell carcinoma
=> both in setting of leukoplakia

Question 8

Non-HPV related squamous cell caricinoma of vulva is caused by what

Answer 8

lichen simplex chronicus
leukoplakia
may be precancerous

Question 9

Non-HPV vulvar carcinoma usually in this population

Answer 9

women > 70

from longstanding lichen sclerosis

Question 10

Extramammary Paget disease

pathology findings

Answer 10

malignant cells found in epidermis
carcinoma in situ
erythemitis, pruritic, ulcerated vulvar skin

Question 11

Extramammary Paget disease vs Paget disease of nipple

Answer 11

both caricnoma in situs
Paget of nipple has underlying breast caricnoma under it
extramammary Paget is standalone in situ carcinoma

Question 12

Extramammary Paget distringuished from what other entity

Answer 12

melanoma

Question 13

How to differentiate extramammary Paget and melanoma

Answer 13

Paget: keratin +, S100-, PAS+
Melanoma: keratin -, S100+, PAS-

Question 14

PAS stain stains for what

Answer 14

mucus secreting cells

only in epithelial tissue ie Paget