Ovarian Tumors Flashcards
Two types of surface epithelial tumors
serous and mucinous
both are usually cystic
BRCA1 mutations cause cancer types in these locations
breast carcinoma
ovarian: serous carcinoma, may also be in fallopian tube
Endometriod ovarian tumors
malginancy potential
associations
usually malignant
associated with endometriosis and endometrial cancer in the endometrium
*if you find endometrial ca in ovary, be sure to look in the endometrium
Brenner tumors
tissue type
bladder-type tissue
Ovarian tumors like to metastasize to where
peritoneum
Tumor marker for epithelial ovarian tumors
CA-125
Struma ovarii
teratoma
composed of primarily thyroid tissue
Immature tissue in teratomas is usually of what type
neural ectoderm
Most common somatic malignancy in teratomas
squamous cell carcinoma
Dysgerminoma is analogous to what male tumor
seminoma
Dysgerminoma
histology
large cells w/ clear cytoplasm
Endometrial sinus tumor
mimics what
mimics yolk sac
Endometrial sinus tumor origin population histology tumor marker
yolk sac
young women/girls
glomeruloid appearance w/ Schiller-Duval bodies
AFP (alpha feta-protein) is tumor marker
Choriocarcinoma
mimics
tumor marker
agressiveness
mimics placenta
hCG is tumor marker
very aggressive, placenta looks for blood vessels
*very early hematogenous spread with multiple mets
Embryonal carcinoma
large primitive cells
early mets
Granulosa-theca cell tumor
produces
Sx
produces estrogen
puberty, menorrhagia
Sertoli-Leydig cell tumor
histology
produces
Sx
Reinke crystals are characteristic
Sertoli and Reinke cells
hirsutism and viralization
Viralization definition
development of male characteristics
Fibroma of ovary
associations
pleural effusions
ascites
Krukenberg tumor
metastatic signet cell/diffuse type gastric carcinoma
mets to bilateral ovaries
often mucinous
Pseudomyxoma peritonei
mucinous tumor of appendix
mets to ovary
large amounts of mucin produced and put into peritoneal cavity
