Cervix Flashcards
Condyloma HPV strains
6, 11
High-risk HPV strains
16, 18, 31, 33
High risk HPV types make these protein virulence factors
E6: destroys p53
E7: destroys Rb
Epithelium in
external cervix
internal cervix
external: stratified squamous
internal: columnar
transformation zone is in between
Most HPV infections happen where in cervix
transition zone
CIN I
CIN II
CIN III
cervical intraepithelial neoplasia (dysplasias until carcinoma)
CIN I:
What differentiates dysplasia and carcinoma
carcinoma is irreversible
dysplasia is reversible
Cervical carcinoma presentation
vaginal bleeding
postcoital bleeding
Other non-HPV risk factors for cervical carcinoma
smoking immunodeficiency (AIDS-defining)
What does it mean to be an AIDS-defining illness
if person has these then they have clinically AIDS patients and not HIV patients
Invasion of cervical cancer
metastisizes late
aggressive local invasion
bladder –> block ureters –> hydronephrosis –> renal failure
Types of cervical cancer
squamous cell
adenocarcinoma
What type of cervical cancer do paps pick up
squamous cell
they follow dysplasia –> carcinoma sequence
adenocarcinoma does not follow this pathway so it is not easily detected
HPV causes what subtypes of cervical cancer
both squamous and adenocarcinoma
How long does it take for dysplasia to move into carcinoma in cervical cancer
10-20 yr
