Volume Of distributon Flashcards
1
Q
If the drug binds to tissue, will the V be large or small?
A
Large
2
Q
Blood volume?
A
Around 5L
3
Q
Formula for Vd?
A
A / C (amount / plasma concentration)
4
Q
Vd helps to determine what?
A
The loading dose that should be given
5
Q
Which dosage form allows you to know exactly what the amount of drug in the body is?
A
IV bolus dose
6
Q
How does molecular weight contribute to the drug’s distribution?
A
If too large, will be unable to penetrate through membranes, meaning it is confined to circulation. E.g. heparin
7
Q
Where are lipophillic drugs most likely to distribute to?
A
ICF and fatty tissue
8
Q
Are weak acids more likely to be in the ICF or ECF?
A
ECF - because they are ionised here so cannot cross membrane. Weak bases are ionised in the ICF, so they stay there
