Half Life And Accumulation Flashcards
1
Q
What value is the slope of the line for the concentration - time profile plotted on semi-logarithmic paper?
A
The k - elimination rate constant
2
Q
Would a drug with a large V have a small or large half life? Explain.
A
Large. A large V indicates drug is in tissue, not circulation. This means less of drug is exposed to eliminating organs = longer half life
3
Q
What would an accumulation index of 1.5 mean?
A
It means that the concentration of drug in the body at steady state is 1.5 times what it was after the first dose.
4
Q
The accumulation of the drug is related to which two variables?
A
Both the dosing interval and half life
