Analysis

Question 1

Define MRT

Answer 1

Mean residence time. The average time the drug molecule stays in the body. Takes into account the absorption and also the elimination

Question 2

Define MAT

Answer 2

Mean absorption / arrival time. The time taken for the drug to reach systemic circulation this changes depending on the dissolution and absorption of the drug

Question 3

AUMC is always larger or smaller than AUC?

Answer 3

Larger

Question 4

Which values / qualities can you extrapolate using a non-compartmental analysis of a drug?

Answer 4

None. Can be used to describe the data you have collected, but cannot be used to extrapolate or predict how the drug might distribute in a different patient.

Question 5

Name two assumptions made in a non-compartmental analysis

Answer 5

No error in assay

Timing of sampling and dosing was exact

Question 6

Compare a compartmental and non-compartmental analysis

Answer 6

Compartmental divides the body up into different sections whereas non-compartmental does not.

Question 7

Cmax?

Answer 7

Maximum concentration reached

Question 8

Relationship between Cmax and Tmax?

Answer 8

Inversely correlated.