Plasma Protein Binding Flashcards
1
Q
Which drugs are more likely to bind to albumin - acidic or basic drugs?
A
Acidic
2
Q
Which plasma protein do basic drugs most frequently bind to?
A
Alpha1-acid-glycoprotein
3
Q
Why is it not clinically significant if the protein binding increases or decreases?
A
Once steady state is reestablished, the concentration of free drug remains the same.
This is because clearance and distribution can increase or decrease to compensate for the change in binding
4
Q
What is most commonly measured in TDM?
A
Total drug concentration
5
Q
Are drugs with extremely high clearance more likely to less likely to be impacted by changes in protein binding?
A
More likely.
The clearance rate might not be able to adjust to the changes in binding
